Search Results for "Adamts Proteases Key Roles In Atherosclerosis"
Original Source: ADAMTS proteases: key roles in atherosclerosis?
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases are secreted enzymes that regulate extracellular matrix turnover by degrading specific matrix components. Roles for the proteases in inflammation and atherosclerosis have been suggested by a number of recent studies, and the role of ADAMTS-4 and -5 in the breakdown of aggrecan and subsequent degradation of cartilage during osteoarthritis has also been established. The ability of the ADAMTS proteases to degrade versican, th...
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Dyslipidemia is a generally asymptomatic disease in which serum lipid levels deviate from the normal level. It is considered to be a modifiable risk factor for cardiovascular disease due to its dire...
'Vascular' relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these stru...
phosphatidylinositol 3 kinase PI3K AKT mTOR Inhibitors
The phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in the regulation of cellular growth, survival, and proliferation. Dysregula...
Naturally occurring vitamin E exists in eight chemical forms (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) that have varying levels of biological act...
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Location, location, location: Membrane 'residence' gives proteases novel abilities
(Johns Hopkins Medicine) Johns Hopkins scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping pr...
Researchers for the first time have shown that members of a family of enzymes known as cathepsins - which are implicated in many disease processes - may attack one another instead of the bodily protei...
What Is Atherosclerosis? What Causes Atherosclerosis?
Atherosclerosis (or arteriosclerotic vascular disease) is a condition where the arteries become narrowed and hardened due to an excessive build up of plaque around the artery wall. The disease disrup...
Scientists discover mechanism that controls obesity, atherosclerosis and potentially cancer
Scientists from the Institute of Molecular and Cell Biology (IMCB) have discovered a new signalling pathway that controls both obesity and atherosclerosis. The team demonstrated, for the first time, t...
iGLuc: a luciferase-based inflammasome and protease activity reporter
A reporter of caspase-1 activity based on Gaussia luciferase—iGLuc—reveals inflammasome activation in mouse cells and in vivo. iGLuc forms nonluminescent aggregates in cells that can be cleaved by...
Groundbreaking discovery of mechanism that controls obesity, atherosclerosis
(Agency for Science, Technology and Research (A*STAR), Singapore) A*STAR scientists have discovered a new signalling pathway that controls both obesity and atherosclerosis. The team demonstrated, for...
Relationship Between CRP and Atherosclerosis Differs on BMI
Does CRP measure up -- for predicting atherosclerosis in obese patients? Journal of the American College of Cardiology
Should We Test Lp(a) to Predict Risk for Atherosclerosis?
Dr Deepak Voora considers the clinical implications of recent data demonstrating an association between lipoprotein(a) levels and atherosclerosis. Medscape Genomic Medicine
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ADAMTS proteases: key roles in atherosclerosis?
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases are secreted enzymes that regulate extracellular matrix turnover by degrading specific matrix components. Roles fo...
ADAMTS: Novel Proteases Expressed by Activated Mast Cells.
Abstract Here we show that mast cells (MCs) express metalloproteases of the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, and that ADAMTS expression is influenced by...
ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) proteases are emerging as key participants in the pathogenesis of vascular diseases. We studied the expression of ADAMTS-...
ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury.
ADAMTS-13, a member of the family of disintegrins and metalloproteinases with thrombospondin motifs, is produced primarily in the liver, particularly by hepatic stellate cells. This metalloproteinase...
The ADAMTS(L) family and human genetic disorders.
ADAMTS designates a family of 19 secreted enzymes, whose the first member ADAMTS1 was described in 1997. The ADAMTS family has a role in extracellular matrix degradation and turn over and has previous...
