Dendritic Cell Vaccine Personalized BiovaxID

Dendritic Cell Vaccine Personalized DCVax

Vaccines

A vaccine is any preparation intended to produce immunity to a disease by stimulating the production of antibodies. It creates immunity but does not cause the disease. There are several differnt typ...

B cells

T cells

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection

Pierre Guermonprez and colleagues have worked out how a subset of dendritic cells expands in individuals with severe malaria. Plasmodium infection causes an accumulation of xanthine in infected red bl...

Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells

In lymph nodes, cellular positioning can dictate the immune response. Lund and colleagues show that nematode infection triggers interactions between lymphotoxin-producing B cells and CXCR5+ dendritic...

Preschool within lymphatic vessels

Not only infants crawl. ETH researchers have shown that so-called dendritic cells, important cells of the immune system, use a similar mode of movement more often than previously assumed. The scientis...

Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

The early events in the pathogenesis of type 1 diabetes remain incompletely understood. Julien Diana et al. now show that in response to physiological beta cell death, innate immune cells including ne...

Immune Tolerance Induced by a Mixture of Cytokines and Dendritic Cells Enhances Gene Therapy

A study carried out in mice has demonstrated the potential for using primed immune dendritic cells to induce immune...

Researchers reveal role of dendritic cells in Type 1 diabetes

The researchers reveal the role of the innate immune cells, especially the dendritic cells, that cause the activation of the killer T-lymphocytes whose action is directed against the p pancreatic cell...

Origins of key immune cells discovered

Neuropathologists have solved the puzzle surrounding the origins of follicular dendritic cells – cells of lymphoid organs that play an important role in many autoimmune and infectious diseases. The...

HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.

Lentiviral vectors (LV) can induce type I interferon (IFN I) production from murine plasmacytoid dendritic cells (pDC), but not myeloid (my)DC. Here, we investigated whether this mechanism is conserve...

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells.

Adoptive T cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19-CAR-transduced T cells in a...

Comparative Analysis of Transduced Primary Human Dendritic Cells Generated by the Use of Three Different Lentiviral Vector Systems.

Lentiviral gene transfer vectors are suitable for genetically modifying non-cycling primary human cells. In this study, we analyzed transduced human dendritic cells (DC) generated by the use of three...

Antitumor effect of murine dendritic and tumor cells transduced with IL-2 gene.

Interleukin (IL-) 2 acts on a number of types of immune cells promoting their effector functions. To replacesystemic administration of recombinant form of this cytokine, various genetically modified c...

Monocytes join the dendritic cell family.

Dendritic cells are professional antigen-presenting cells that mediate immunity and tolerance. Cheong et al. (2010) uncover a new route for dendritic cell production in vivo. They show that in respo...