Search Results for "Alkyne Label"
Original Source: Cleavable Biotin Probes for Labeling of Biomolecules via Azide-Alkyne Cycloaddition.
The azide-alkyne cycloaddition provides a powerful tool for bio-orthogonal labeling of proteins, nucleic acids, glycans, and lipids. In some labeling experiments, e.g., in proteomic studies involving affinity purification and mass spectrometry, it is convenient to use cleavable probes that allow release of labeled biomolecules under mild conditions. Five cleavable biotin probes are described for use in labeling of proteins and other biomolecules via azide-alkyne cycloaddition. Subsequent to conjugation with...
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Lupus : A major unmet medical need Lupus is a chronic and severe autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and t...
The chimeric anti-CD20 antibody rituximab (Rituxan & MabThera) from Biogen Idec and Genentech/Roche is one of the world’s commercially most successful antibodies (2007 sales of over US$ 5 bl...
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EMBL Chemical Biology: Labeling Proteins
Jason Chin of the MRC Molecular Biology lab in the UK has been talking here about protein labeling and genetic code expansion, an overview of the numerous papers his group has been publishing in this...
EMBL Chemical Biology: Greasy Labels
Just to emphasize how careful you have to be with all these probes and labels, consider what I'm hearing now from Remigiusz Serwa of the Tate group at Imperial College. His group is looking at farnesy...
Novel chemotherapies more often used on- than off-label
(HealthDay)—In contemporary practice, medical oncologists use novel anticancer agents on-label more often than off-label, according to a study published online Feb. 19 in the Journal of Clinical Onc...
Put this one in the category of "reactions you probably wouldn't have thought of". There's a new paper in Organic Letters on cleaving a carbon-carbon triple bond, yielding the two halves as their own...
Disclosure Not Necessary For Off-Label Drug Use; Patients May Not Know They're Taking Them
Many people have probably heard of off-label drug use, but they may not know when that applies to prescriptions they are taking, a Mayo Clinic analysis found. Off-label drug use occurs when a physicia...
Off-label drug use common, but patients may not know they're taking them, study finds
Many people have probably heard of off-label drug use, but they may not know when that applies to prescriptions they are taking, a Mayo Clinic analysis found. Off-label drug use occurs when a physicia...
ICM Trading, iTrade Capital Markets Invite Investors To Become White Label Partners
New York (PRWEB) January 18, 2013 ICM trading offers investors an opportunity to become a white label partner. The white label partnership is one of the best ways for banks and brokers to satisfy...
LONDON, July 3, 2012 /- The inherent advantages of label-free technology is a significant factor in driving its adoption. The promise of reducing drug failure caused by toxicity is ano...
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A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.
A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change...
The alkyne-azide Cu(I)-catalyzed Huisgen cycloaddition, a click-type reaction, was used to label a double-stranded oligonucleotide (siRNA) with fluorine-18. An alkyne solid support CPG for the prepara...
The use of the bulky hydrotris(3-mesitylpyrazolyl)borate anionic ligand has allowed the synthesis of stable Tp(Ms)Cu(alkyne) complexes (alkyne = 1-hexyne, 1, phenylacetylene, 2, and ethyl propiolate,...
Squish and CuAAC: Additive-Free Covalent Monolayers of Discrete Molecules in Seconds.
A terminal alkyne is immobilized rapidly into a full monolayer by squishing a small volume of a solution of the alkyne between an azide-modified surface and a copper plate. The monolayer is covalently...
Isolable Tris(alkyne) and Bis(alkyne) Complexes of Gold(I).
Golden trefoils: Tris(alkyne)gold complex [(coct)(3) Au][SbF(6) ] (see picture; 1-SbF(6) ) can be synthesized from cyclooctyne (coct) and AuSbF(6) generated in situ. Treatment of AuCl with cycloocty...
