Search Results for "Allopurinol Azathioprine"
Original Source: Azathioprine & Allopurinol in Inflammatory Bowel Disease Patients
Main Study Objectives: The study is conducted to - evaluate the minimal allopurinol and azathioprine doses that, in combination, produce therapeutic 6-TGN levels - evaluate the safety and tolerability of the different allopurinol/azathioprine dose levels - assess if concomitant allopurinol affects TPMT activity - assess the clinical efficacy of concomitant allopurinol-azathioprine therapy in the included patients
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Acute Lymphocytic Leukemia ALL
Acute lymphocytic leukemia (ALL) is a life-threatening disease in which the cells that normally develop into lymphocytes become cancerous and rapidly replace normal cells in the bone marrow. ALL acc...
Ulcerative colitis is a disease that affects around 120,000 people in the UK and causes inflammation of the large intestine - or colon. Symptoms vary in severity from pain and discomfort, through mu...
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A Less Risky Allopurinol Approach
A study seeks to identify the optimal allopurinol dose, balancing efficacy with risk for allopurinol hypersensitivity syndrome. Medscape Rheumatology
Starting Allopurinol at Higher Dose Increases Risk for AHS
Patients with gout who start allopurinol at a dose less than 1.5 mg/mL of estimated GFR and slowly increase to therapeutic levels are less likely to develop allopurinol hypersensitivity syndrome. M...
Starting Dose of Allopurinol in Gout
A study seeks to make walking the efficacy-safety tightrope of allopurinol therapy a little less risky. Medscape Rheumatology
Crystal arthritis: Is HLAB genotyping the future of gout pharmacogenomics?
Pharmacogenomic advances have increased understanding of allopurinol-associated severe cutaneous adverse reactions (SCARs), demonstrating that HLAB*5801 is a strong risk factor for their development....
Allopurinol may improve CV outcomes in kidney disease
The xanthine oxidase inhibitor allopurinol appears to be beneficial in preventing cardiovascular morbidity and all-cause mortality in patients with hypertensive nephropathy, show findings from a Japan...
Azathioprine exposure concerns raised for SLE mothers
Researchers have raised the possibility of an increased risk for developmental delay in the children of mothers who used azathioprine for systemic lupus erythematosus during pregnancy.
REFILE: Azathioprine exposure in utero may contribute to developmental delays
NEW YORK (Reuters Health) - In utero exposure to azathioprine may be associated with increased utilization of special educational services, researchers say.
Allopurinol: Severe Cutaneous Reactions Rare but Serious
Severe cutaneous reactions requiring hospitalization are rare but occurred 10 times more often among patients beginning allopurinol treatment, and most often in the first 180 days of use. Medscape...
Matching PubMed Articles
PURPOSE: Recent studies in patients with inflammatory bowel diseases (IBD) on thiopurine therapy suggest that too low 6-thioguanine nucleotide concentrations (6-TGN) and too high methylmercaptopurine...
Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis.
We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is k...
Gout in pediatric renal transplant recipients.
Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who pres...
Thiopurine therapy effectively maintains remission in inflammatory bowel disease. However, many patients are unable to achieve optimum benefits from azathioprine or 6-mercaptopurine because of undesir...
