Search Results for "Alpha And Beta Estrogen"
Original Source: Roles of estrogen receptors alpha and beta in sexually dimorphic neuroprotection against glutamate toxicity.
Although most agree that 17β-estradiol is neuroprotective via a variety of mechanisms, less is known about the role that biological sex plays in receptor-mediated estradiol neuroprotection. To address this issue we isolated primary cortical neurons from rat pups sorted by sex and assessed the ability of estradiol to protect the neurons from death induced by glutamate. Five-minute pretreatment with 10-50 nM 17β-estradiol protected female but not male neurons from glutamate toxicity 24 h later. Both estroge...
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Interleukin 1 IL 1 Receptor IL 1R
Interleukin-1 (IL-1) beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. Current therapy targetin...
Selective Estrogen Receptor Modulators SERMs
Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists or antagonist depending on the targeted tissue and the specific configuration of the used SERM. Effects on bone, e...
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Reprogramming Alpha Cells To Fight Diabetes
Rather than trying to reactivate the insulin-producing beta cells, researchers say that reprogramming the alpha cells into beta cells may be a better route to take in order to treat type 2 diabetes. T...
Reprogramming alpha cells into beta cells to Fight Diabetes
For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The “reprogramming” of related alpha cells...
Estrogen Pills May Help as MS Add-on (CME/CE)
LYON, France (MedPage Today) -- High-dose estrogen supplements added to standard interferon-beta therapy in multiple sclerosis could increase treatment responses in at least some women, a researcher s...
Reprogramming cells to fight diabetes
(University of Pennsylvania School of Medicine) For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "re...
Polymorphism in estrogen receptor alpha linked to back pain
(HealthDay)—For women with degenerative spondylolisthesis (DS), polymorphisms in the estrogen receptor α (ERα) are associated with back pain intensity, according to a study published in the April...
Cyclodextrins as Therapeutics for Lysosomal Storage Disorders
Cyclodextrins (CD), alone or in combination with other agents (e.g., vitamin E), as therapeutics for the treatment of lysosomal storage disorders (LSDs) caused by the accumulation of non-cholesterol l...
Will 2013 Be A Big Year For GTx?
ByC.R. Jackson:Memphis, Tennessee-based GTx, Inc. (GTXI) is a 265M market cap biopharmaceutical company that is developing Ostarine (enobosarm), an androgen receptor modulator, which is in Phase 3 cli...
Metabolic Dysfunction Under Reduced Estrogen Levels
Can exercise replace estrogen therapy in women with reduced estrogen function? Exercise and Sport Sciences Reviews
Matching PubMed Articles
PURPOSE: The study was designed to investigate the clinicopathological correlations, relationship to apoptotic index, and prognostic significance of estrogen receptor beta expression in colorectal car...
Obesity is associated with the increased incidence of colon cancer. Many cancer risk factors have been identified including increased blood levels of insulin, leptin, interleukin-6, interleukin-17, tu...
Human estrogen receptors alpha and beta are crucially involved in the regulation of mammary growth and development. Normal breast tissues display a relative higher expression of ER beta than ER alpha,...
The aim of the present study was to assess and compare the effect of 17β-estradiol and two different selective estrogen receptor modulators (SERMs), tamoxifen and raloxifene, as well as a selective e...
Upregulated estrogen receptor β2 in chronic lymphocytic leukemia.
Abstract The estrogen receptors alpha (ERα) and beta (ERβ) have been demonstrated in mouse models to be important for immune system regulation and are differentially expressed in lymphoid organs. On...
