Anti Infective Peptides

Anti-viral peptides are used to treat infections such as HIV and AIDS, influenza incl. H5N1 strains, hepatitis C virus infections (HCV). Anti-bacterial peptides are used to treat infectiou...

Plasmid Land: The Plasmid Cloning Game

When the average person asks, “What is a plasmid?” we sometimes struggle to give them a basic answer. Plasmids are circular fragments of double-stranded DNA that can replicate independen...

Anti-Inhibitor Coagulant Baxter

Anti-Inhibitor Coagulant Nabi

Antisense

Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synth...

A Novel Double-Stranded DNA Structure Identified

Double-stranded DNA has often been described as a right-handed helical structure, known as B-DNA. To perform its multiple functions, double-stranded DNA has multiple structures depending on conditions...

Natural GMOs Part 165. Novel double-stranded RNAs get served up in many conventional crops — such as rice.

(An earlier version of this post appeared at GMO Pundit blog.) Some people have raised worries about whether novel double-stranded RNA molecules present in plant foods might be harmful to people. Natu...

Researchers identify a novel double-stranded DNA structure

Addressing a scientific debate that had lasted for 16 years over the existence of a certain type of double-stranded DNA structure called S-DNA, researchers in Singapore were able to create the stru...

S-DNA: novel double-stranded DNA structure identified

Double-stranded DNA has often been described as a right-handed helical structure, known as B-DNA. To perform its multiple functions, double-stranded DNA has multiple structures depending on conditions...

DNA's double stranded stretch

(Springer) Theoretical physicists like to play with very unconventional toys. Manoel Manghi from Toulouse University in France and his colleagues have adopted a seemingly playful approach to examining...

Targeting double-stranded RNA dependent protein kinase could treat inflammation

Researchers at The Feinstein Institute for Medical Research have discovered that inflammation could be treated by targeting a molecule called the double-stranded RNA dependent protein kinase (PKR). Th...

What is the role of double-stranded RNA in antiviral host defense systems?

(Mary Ann Liebert, Inc./Genetic Engineering News) Animals, insects, and plants use a variety of sensing mechanisms to detect invading pathogens such as viruses. One complex and effective antiviral def...

The Role Of Double-Stranded RNA In Antiviral Host Defense Systems

Animals, insects, and plants use a variety of sensing mechanisms to detect invading pathogens such as viruses. One complex and effective antiviral defense system they share is based on recognition of...

Double-stranded oligonucleotides containing 5-aminomethyl-2'-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA.

This Letter describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with...

Medical conditions associated with a positive anti-double-stranded deoxyribonucleic acid.

OBJECTIVE: To explore the associated diseases with positive anti-double stranded (ds) DNA other than systemic lupus erythematosus (SLE), and to determine an association if any, between its level in no...

Rap1 Binds Single-stranded DNA at Telomeric Double- and Single-stranded Junctions and Competes with Cdc13 Protein.

The ends of eukaryotic chromosomes are protected by specialized telomere chromatin structures. Rap1 and Cdc13 are essential for the formation of functional telomere chromatin in budding yeast by bindi...

Ultrasensitive and facile electrochemical deoxyribonucleic acid biosensor based on the conformational change of the recognition interface.

An ultrasensitive electrochemical impedance spectroscopic deoxyribonucleic acid biosensor has been developed based on the conformational change of the deoxyribonucleic acid recognition interface with...

A novel fluorescent biosensor for sequence-specific recognition of double-stranded DNA with the platform of graphene oxide.

A fluorescent biosensor for sequence-specific recognition of double-stranded DNA (dsDNA) was developed based upon the DNA hybridization between dye-labeled single-stranded DNA (ssDNA) and double-stran...