Analgesic Nephropathy

Opioid Analgesics

Opioid antagonists

Adjuvant Analgesic Drugs

Opioid Abuse and Rehabilitation

Cara's PhII analgesic reducing morphine use in acute post-operative pain

The US venture Cara Therapeutics has reported that its novel, peptide-based peripherally-acting kappa opioid agonist, CR845, met its goals in a Phase II placebo-controlled trial when administered as a...

Wide Variation in Guidance for Opioid Dosing

NEW ORLEANS (MedPage Today) -- Opioid analgesic conversion guidelines offer conflicting information and are generally based on single-dose studies with no long-term data, researchers reported here.

Selective Opioid Receptor Inhibitor Relieves Constipation

An investigational, selective mu-opioid receptor inhibitor improved constipation in patients on opioids in randomized phase 2 trial without interfering with analgesic effects. Medscape Medical News

Nektar Announces Start of Enrollment in Phase 2 Study of NKTR-181, a Novel Opioid Analgesic ...

Favorable AcelRx Stock Offering Price May Catalyze The Company's Share Price

By Chemistfrog:AcelRX Pharmaceuticals (ACRX) has had an impressive year behind it culminating with the completion of three phase 3 trials for its NanoTab™ platform's ARX-01. The therapy is a subling...

Reduced Pain, Opioid Use, and Opioid-Related Adverse Events in Patients Receiving EXPAREL® Compared With Patients Receiving Bupivacaine HCl as a Component of Multimodal Therapy

Pacira Pharmaceuticals, Inc. (NASDAQ: PCRX) today announced the publication of results from a pooled analysis of nine clinical trials across five surgical models that compa...

Lubiprostone Effective for Opioid-Induced Constipation

Phase 3 study shows the drug was well tolerated, improved constipation without compromising analgesic response. Medscape Medical News

FDA OKs new indication for Janssen's Nucynta and fast tracks Zytiga sNDA

There were two pieces of good news for US health care giant Johnson & Johnson (NYSE: JNJ) subsidiaries yesterday. First, the US Food and Drug Administration has approved Janssen Pharmaceuticals' suppl...

The kappa opioid receptor agonist SA14867 has antinociceptive and weak sedative effects in models of acute and chronic pain.

We examined the analgesic effect of the selective kappa opioid receptor agonist SA14867 and the balance of its antinociceptive and sedative effects. The ED(50) values of SA14867 after oral administrat...

TH-030418: a potent long-acting opioid analgesic with low dependence liability.

Numerous efforts have been made on the chemical modification of opioid compounds, with the ultimate goal of developing new opioid analgesics that is highly potent and low/non-addictive. In a search fo...

Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice.

SCOPE: We found that rubiscolin-6, a δ opioid agonist peptide derived from d-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), a major protein of green leaves, stimulates food intake after o...

The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.

Opioid-induced constipation (OIC) is associated with negative impact of opioid analgesics on opioid receptors located in the gut wall. Until recently, OIC was treated symptomatically only, with differ...

Interaction of supraspinally administered interferon-alpha with opioid system in the production of antinociception.

We examined the antinociceptive effect of intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered of interferon-alpha (IFN-alpha) using the tail-flick analgesic test in mice. IFN-alpha...