Search Results for "Artemisinin Prions"
Original Source: Molecular Basis for Transmission Barrier and Interference between Closely Related Prion Proteins in Yeast.
Replicating amyloids, called prions, are responsible for transmissible neurodegenerative diseases in mammals and some heritable phenotypes in fungi. The transmission of prions between species is usually inhibited, being highly sensitive to small differences in amino acid sequence of the prion-forming proteins. To understand the molecular basis of this prion interspecies barrier, we studied the transmission of the [PSI(+)] prion state from Sup35 of Saccharomyces cerevisiae to hybrid Sup35 proteins with prion...
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Just What Are Protective Prions?
Most commonly associated with such maladies as "mad cow disease" and Creutzfeldt-Jakob disease, prions are increasingly recognized for their ability to induce potentially beneficial traits in a variet...
Crows don't digest prions, may transport them to other locations
(Public Library of Science) Crows fed on prion-infected brains from mice can transmit these infectious agents in their feces and may play a role in the geographic spread of diseases caused by prions,...
Exosomes Infected with Prions Diagnostic for vCJD
Newly available genetic sequencing enables scientists to discover cells infected with prions, the infectious agent responsible Creutzfeldt-Jakob disease...
Prions may be crucial in brain development during childhood
A molecule that is not only dangerous, but can help the brain grow. A few years ago it was found that certain proteins, the prions, when defective are dangerous, as they are involved in neurodegenerat...
Piperaquine/artemisinin product Eurartesim launched for P falciparum malaria
Piperaquine and artemisinin combination tablets have been launched in the UK for the treatment of adults and children...
Launch of semi-synthetic artemisinin a milestone for malaria, synthetic biology
(University of California - Berkeley) The best therapy today for malaria is a drug combination that includes a derivative of artemisinin, now solely available from plants grown in Asia and Africa. On...
IU chemists develop fully synthetic artemisinin to help reduce cost of live-saving drugs
In 2010 malaria caused an estimated 665,000 deaths, mostly among African children. Now, chemists at Indiana University have developed a new synthesis for the world's most useful antimalarial drug, art...
New compounds inhibit prion infection
Researchers have identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals. Scientists...
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Continuous-flow synthesis of the anti-malaria drug artemisinin.
Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annu...
Murine prions transferred from brain to cultured cells gradually adapt to the new environment. Brain-derived 22L prions can infect neuroblastoma-derived PK1 cells in the presence of swainsonine (swa);...
Fungal Prions: Structure, Function and Propagation.
Prions are not uniquely associated with rare fatal neurodegenerative diseases in the animal kingdom; prions are also found in fungi and in particular the yeast Saccharomyces cerevisiae. As with animal...
Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.
Artemisinin, a sesquiterpene lactone isolated from the Chinese medicinal plant Artemisia annua L., is an effective antimalarial agent, especially for multi-drug resistant and cerebral malaria. To date...
Prions consist mainly, if not entirely, of PrP(Sc), an aggregated conformer of the host protein PrP(C). Prions come in different strains, all based on the same PrP(C) sequence, but differing in their...
