Search Results for "Articles On Innate Immunity"
Original Source: Defensins in innate immunity.
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in leukocytes, playing an important role in the innate immune system due to their antimicrobial, chemotactic and regulatory activities. This review introduces their str...
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Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. TLRs have become attractive targets for activation or antagonism in pharmaceutical research. TLR ag...
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The history of Toll-like receptors — redefining innate immunity
The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the identification of Toll-like receptors as the...
Innate immunity: Epithelial cells ACT up in worm expulsion
Epithelial cells mediate immunity to helminths by promoting type 2 innate effector cell responses.
Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses
Invertebrates lack conventional antibody-based immunity but have the capacity to distinguish between symbionts and pathogens. In this Review, Nyholm and Graf describe how the innate immune system of f...
Population genetic tools for dissecting innate immunity in humans
Population genetics informs about how genes have evolved under varying selective pressures. The analysis of such selection signatures in innate immune genes, including genes encoding pattern-recogniti...
Innate immunity system of sheep and goat herds against viral infections clarified
(Elhuyar Fundazioa) Biology and Biochemistry graduate, Paula Jáuregui Onieva, has undertaken research for her PhD thesis on the factors of restriction of innate immunity present in sheep and goats. I...
Innate immunity: Destructive interference of PRRs
Viral infections activate innate immune signalling pathways that impair the clearance of co-infections with bacteria.
Innate immunity: TLR13, unlucky, but just for some
An antibiotic evasion strategy in bacteria also confers resistance to the innate immune sensor TLR13.
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Innate immunity in the control of HIV/AIDS: recent advances and open questions.
From the publication of the first AIDS issue onwards, major advances have been made in the field of innate immunity during HIV infection. Innate immunity can be defined as the first and unspecific lin...
Illuminating the latest advances in innate immunity on the island of the sun god.
The latest Aegean Conferences workshop on innate immunity (Rhodes, Greece) discussed recent developments that suggest that innate immune mechanisms are not restricted to providing first-line defense o...
Innate immunity in the central nervous system.
Immune responses in the CNS are common, despite its perception as a site of immune privilege. These responses can be mediated by resident microglia and astrocytes, which are innate immune cells withou...
Innate immunity and adjuvants.
Innate immunity was for a long time considered to be non-specific because the major function of this system is to digest pathogens and present antigens to the cells involved in acquired immunity. Howe...
Identifying novel spatiotemporal regulators of innate immunity.
The innate immune response plays a critical role in pathogen clearance. However, dysregulation of innate immunity contributes to acute inflammatory diseases such as sepsis and many chronic inflammator...