Search Results for "Autism Nmda"
Original Source: Targeting of Glycine Site on NMDA Receptor as a Possible New Strategy for Autism Treatment.
The exact pathophysiology of the neurodevelopment disorder of autism is not clear and there is not any curative approach for it. There is only one FDA-approved medication for its management. Therefore, providing of novel treatments is highly required. The hypofunction of GABAergic system and glutamate toxicity are generally believed to have a causal role for autism. The antagonist of the N-methyl-D: -aspartic acid (NMDA) glutamate receptor improves autism. Glycine is required for the activation of NMDA rece...
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Autism affects half a million people in the UK. Men are affected more than women. People with autism have said that the world, to them, is a mass of people, places and events which they struggle t...
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Synaptic physiology: It takes two for NMDA receptors
Hippocampal pyramidal cell synapses have NMDA receptors located synaptically and extrasynaptically. Papouin et al. now show that these two populations of receptors have different subunit compositions,...
The hippocampus as a decision-maker
(Medical Xpress) -- Synapses are modified through learning. Up until now, scientists believed that a particular form of synaptic plasticity in the brain’s hippocampus was responsible for learning...
Janssen, Evotec join forces to develop NMDA antagonist portfolio
Evotec has signed a license agreement with Janssen Pharmaceuticals to develop its NR2B subtype selective NMDA-antagonist portfolio against diseases in the field of depression.
Evotec announces NMDA antagonist license agreement with Janssen Pharmaceutical
Evotec has entered into a license agreement with Janssen Pharmaceuticals, regarding its NR2B subtype selective NMDA-antagonist portfolio for development against diseases in the field of depression. ...
Type: Original PaperPurposeTo explore the role of the High Mobility Group Box 1 (HMGB1) protein in NMDA-mediated excitotoxicity in rat cortical neurons.MethodsWe knocked down HMGB1 using small-interfe...
MindSpec develops Autism Quiz app
(MindSpec) To spread public knowledge of autism research, MindSpec has created a new Autism Quiz social media app which allows the general public to test autism knowledge and share facts about autism...
Autism Speaks and SAGE® Labs develop rat models for translational autism research
(Autism Speaks) Autism Speaks and Sigma Advanced Genetic Engineering Labs are expanding their collaboration to develop the first rat models with modified autism associated genes, intended to accelerat...
Evotec in up to $175 million NMDA antagonist license deal with Janssen
Germany's Evotec (EVT: TecDAX) has entered into a license agreement with Janssen Pharmaceuticals, a subsidiary of US health care giant Johnson & Johnson (NYSE: JNJ) regarding its NR2B subtype selectiv...
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Targeting of Glycine Site on NMDA Receptor as a Possible New Strategy for Autism Treatment.
The exact pathophysiology of the neurodevelopment disorder of autism is not clear and there is not any curative approach for it. There is only one FDA-approved medication for its management. Therefore...
Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders.
N-Methyl-d-aspartate (NMDA) receptor, one of the glutamate receptors, has a role in the regulation of synaptic activity. It functions as an ion channel in the central nervous system and its inappropri...
The promise and the pitfalls of autism research: An introductory note for new autism researchers.
The last decade has seen an enormous growth in the quantity of research directed at understanding the biological underpinnings of autism spectrum disorders. This increase has been spurred on, in part,...
Middle School Students' Knowledge of Autism.
Authors examined 1,015 middle school students' knowledge of autism using a single item of prior awareness and a 10-item Knowledge of Autism (KOA) scale. The KOA scale was designed to assess students'...
Knowledge and Attitude of General Practitioners Regarding Autism in Karachi, Pakistan.
General practitioners (GPs) could have an important role in early diagnosis of autism. There have been no studies evaluating the knowledge of GPs regarding autism in Pakistan. We aimed to fill that ga...
