Search Results for "Autophagy Pancreatic Cancer Cells"
Original Source: Autophagy in pancreatic cancer: an emerging mechanism of cell death.
Pancreatic cancer, the fourth leading cause of cancer-related death in the United States, is resistant to current chemotherapies. Therefore, identification of different pathways of cell death is important to develop novel therapeutics. Our previous study has shown that triptolide, a diterpene triepoxide, inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in vivo. However, the mechanism by which triptolide kills pancreatic cancer cells was not known, hence, this study aimed at...
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The pancreas secretes a number of important hormones into the digestive tract and the blood stream. Cancers are most commonly exocrine than endocrine (neuroendocrine) tumors. Functional tumors secre...
Epithelial cell adhesion molecule EpCAM CD326
Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...
Lyxumia® is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) for the treatment of patients with type 2 diabetes mellitus. GLP-1 is a naturally-occurring peptide hormone that is re...
According to the American Brain Tumor Association, just over 24,000 patients will be diagnosed with a primary malignant brain tumour during 2012 in the US alone. Some 80% of primary malignant brain...
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Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine
The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse themselve...
Self-eating cells aid cancer therapy research
Impeding cells from digesting parts of themselves – a process called autophagy – could play a key role in improving therapies for cancer, says a Simon Fraser University researcher and B.C. Cancer...
Critical Molecular Switch Discovered That Regulates Autophagy
The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural deg...
In a landmark cancer study, researchers have unraveled a longstanding mystery about how pancreatic tumor cells feed themselves, opening up new therapeutic possibilities for a notoriously lethal diseas...
Potential Loophole Discovered In Pancreatic Cancer Defenses
Dana-Farber Cancer Institute scientists and colleagues have discovered that pancreatic cancer cells' growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with tar...
Identification of a candidate therapeutic autophagy-inducing peptide
A cell-permeable peptide is constructed that is derived from a region of an essential autophagy protein called beclin 1; the peptide is a potent inducer of autophagy in mammalian cells and in vivo in...
Scientists discover critical molecular switch that regulates autophagy
The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural deg...
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Autophagy in pancreatic cancer: an emerging mechanism of cell death.
Pancreatic cancer, the fourth leading cause of cancer-related death in the United States, is resistant to current chemotherapies. Therefore, identification of different pathways of cell death is impor...
Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells.
PURPOSE: Although fenretinide (4-HPR) has been studied in breast cancer and in neuroblastoma, little is known regarding its activity in pancreatic cancer, a neoplasm for which there are few therapeuti...
Autophagy can play an important part in protecting host cells during virus infection, and several viruses have developed strategies by which to evade, or even exploit, this homeostatic pathway. Tissue...
Interplay between autophagy and apoptosis in pancreatic tumors in response to gemcitabine.
Pancreatic cancer is an aggressive disease. Its incidence has increased over the last two decades. It is currently the fourth cause of death among cancers in the western world. Unfortunately, systemic...
The RB-E2F1 Pathway Regulates Autophagy.
Autophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence suggests that this cellular process is also a tumor suppressor pathway. Previous studies showed...
