Top 50 Biopharma Products 2011

Ronald A. Rader, president of the Biotechnology Information Institute provided Contract Pharma a list of the Top 57 Biopharma Products by 2011 revenues (in millions). Mr. Rader subscribes to the sam...

Avastin unraveled by stratification study, Roche seeks validation

Reanalysis of Avastin registration trial brings Roche strategy for making universal Avastin use in oncology into question again. Study suggests less than half of Avastin treated colorectal cancer pat...

ASCO: continued Avastin after progression increases overall survival in colon cancer

In metastatic colorectal cancer patients who had a follow-up round of second-line Roche/Genentech’s Avastin (bevacizumab) after their disease worsened following initial Avastin plus first-line c...

Avastin Wins FDA Approval For Colorectal Cancer Treatment

The U.S. Food and Drug Administration (FDA) has approved use of Roche's Avastin for patients with colorectal cancer that has gotten worse despite treatment with the medication. This new approval will...

Roche's Avastin Approved For Colon Cancer Treatment By FDA

The U.S. Food and Drug Administration (FDA) has approved use of Roche's Avastin for patients with colorectal cancer that has gotten worse despite treatment with the medication. This new approval will...

Continued Avastin Extends Survival After First Progression in Advanced Colorectal Cancer

Combined second-line treatment with Avastin® (bevacizumab) and standard chemotherapy extends survival in patients with advanced colorectal cancer who have received first-line combined Avastin treatme...

Lilly's Alimta misses maintenance therapy endpoint in NSCLC

Eli Lilly and Co. (NYSE:LLY) said maintenance therapy with Alimta pemetrexed plus Avastin bevacizumab missed the primary endpoint of improving median overall survival (OS) vs. Avastin alone in the Pha...

New England Compounding Center: the Avastin/Lucentis connection

Long-time readers of the blog are aware of my ongoing fixation on the repackaging of the colorectal cancer drug Avastin for injection into the eye to treat wet age related macular degeneration. Genent...

Rerun: Two views on the Avastin/Lucentis debate

The Health Business Blog is taking a break this week, and re-running some posts from August 2008. If you’d like to comment, please do so on the original post. Regular readers remember last ye...

Impact of taxol on dermal papilla cells - A proteomics and bioinformatics analysis.

Dermal papilla (DP) cells play a regulatory role in hair growth, and also play a role in alopecia (hair loss). However, effects of taxol, which is a widely used chemotherapy drug, on DP cells remain u...

Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP(3)R.

Paclitaxel (Taxol) is a microtubule-stabilizing compound that is used for cancer chemotherapy. However, Taxol administration is limited by serious side effects including cardiac arrhythmia, which cann...

Taxol promising fungal endophyte, Pestalotiopsis species isolated from Taxus cuspidata.

The endophytic fungi, Pestalotiopsis versicolor and Pestalotiopsis neglecta, were isolated from the healthy leaves and bark of the Japanese Yew tree, Taxus cuspidata. The fungal species were identifie...

Taxol Directly Induces Endoplasmic Reticulum-Associated Calcium Changes That Promote Apoptosis in Breast Cancer Cells.

  Calcium, a key regulator of cell survival, is also important in regulating apoptosis. Although the chemotherapeutic agent Taxol employs apoptosis to induce cell death, the exact mechanism of how i...

A combination of taxol infusion and human umbilical cord mesenchymal stem cells transplantation for the treatment of rat spinal cord injury.

BACKGROUND AND PURPOSE: Studies have shown that the administration of Taxol, an anti-cancer drug, inhibited scar formation, promoted axonal elongation and improved locomotor recovery in rats after spi...