Structure

Tumor Antigens

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor antigens are useful in identifying tumor cells and are potential candidates f...

Bioscience - news, views, reports and blogs

Bioscience - any of the sciences that deal with living organisms.  The study of the nature, behavior, and uses of living organisms as applied to biology. Any of the branches of natural scienc...

Rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic systemic disease characterized by progressive joint deformity and joint destruction driven by synovial inflammation and hyperplasia in which cytokines play cen...

PKC (Protein Kinase C)

PKC (protein kinase C) http://www.bioportfolio.com/channels/serine-threonine-protein-kinase-c-pkc is a kinase enzyme and a protein molecule that can change the format of other proteins through chemi...

BioFocus signs compound management agreement with eMolecules, Inc

Saffron Walden, UK and Solana Beach, USA; 08 October 2010 – BioFocus, a leading provider of integrated gene-to-clinical candidate drug discovery services and eMolecules, Inc., the creators...

Screening compound resynthesis services from Chemonaut and iThemba Pharmaceuticals

iThemba Pharmaceuticals and Chemonaut announce a collaboration on providing a screening compound re-synthesis service. The collaboration has stemmed from both companies recognising that in the dy...

Structure of the agonist-bound neurotensin receptor

The X-ray crystal structure of a rat neurotensin receptor in complex with the C-terminal portion of neurotensin is presented; this is the first structure of a member of the β group of class A G-prote...

Researchers determine structure of ‘batteries’ of the biological clock

Howard Hughes Medical Institute scientists have determined the three-dimensional structure of two proteins that help keep the body's clocks in sync. The proteins, CLOCK and BMAL1, bind to each other t...

China FDA Revises Compound Qingdai Pill Label

China FDA has revised Compound Qingdai Pill’s labeling for the pill, tablet, and capsule forms.

Intrinsically disordered proteins: A conversation with Rohit Pappu

If you open any biology textbook to the section on proteins, you will learn that a protein is made up of a sequence of amino acids, that the sequence determines how the chain of amino acids folds into...

Atomic-scale determination of surface facets in gold nanorods

The atomic structure of nanoparticles considerably influences their properties. A new methodology that is now able to measure the full three-dimensional atomic structure of free-standing nanoparticles...

Internal bone structure reveals loading and walking behavior

The form and structure of bones change as a result of the forces to which they are subjected. Researchers have used this fact to determine the load using the bone structure. This knowledge can be impo...

AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts.

Neuroblastoma is a common pediatric tumor characterized by clinical heterogeneity. Because it is derived from sympathetic neuroblasts, the NTRK family of neurotrophin receptors plays an integral role...

Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC.

Head and neck squamous cell carcinoma (HNSCC) is a biologically aggressive disease that has been modestly impacted by improvements in therapeutic strategies. Several lines of evidence support the role...

Structural Analysis, Spectroscopic, and Magnetic Properties of the 1D Triple-Bridged Compounds M(dca)(2)(bpa) (M = Mn, Fe, Co, Zn; dca = dicyanamide; bpa = 1,2-bis(4-pyridyl)ethane) and the 3D Ni(dca)(bpa)(2)dca·6H(2)O.

The family of compounds [Mn(dca)(2)(bpa)] (1), [Fe(dca)(2)(bpa)] (2), [Co(dca)(2)(bpa)] (3), [Zn(dca)(2)(bpa)] (4), and [Ni(dca)(bpa)(2)]dca·6H(2)O (5), with dca = dicyanamide and bpa = 1,2-bis(4-pyr...

Does Compound I Vary Significantly between Isoforms of Cytochrome P450?

The cytochrome P450 (CYP) enzymes are important in many areas, including pharmaceutical development. Subtle changes in the electronic structure of the active species, Compound I, have been postulated...

New alkylated benzoquinone from Iris nepalensis.

Chemical investigation of chloroform extract of rhizomes of Iris nepalensis yielded new alkylated 1,4-benzoquinone derivative (1). The structure of Compound 1 was established by analysis of spectrosco...