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A switching cascade of hydrazone-based rotary switches through coordination-coupled proton relays

Metal cations play an important role in biological proton relays by modulating the pKa values of surrounding amino acids. This effect has now been used to induce the isomerization of two hydrazone swi...

Pharmaceutical Research: Pharmaceutical Differences Between Block Copolymer Self-Assembled and Cross-Linked Nanoassemblies as Carriers for Tunable Drug Release

Type: Original PaperPurposeTo identify the effects of cross-linkers and drug-binding linkers on physicochemical and biological properties of polymer nanoassembly drug carriers.MethodsFour types of pol...

CytRx raises $20 million in follow-on

CytRx Corp. (NASDAQ:CYTR) raised $20 million through the sale of 8 million shares at $2.50 in a follow-on underwritten by Aegis Capital. CytRx was off $0.61 (20%) $2.50 on Thursday. CytRx's pipeline i...

Pharmaceutical Research: Preparation, Drug Release, and Cell Growth Inhibition of a Gelatin: Doxorubicin Conjugate

Type: Original PaperPurposeTo demonstrate the feasibility of a novel macromolecular delivery system for doxorubicin (DOX) which combines pH dependent DOX release with a high molecular weight and biode...

Pharmaceutical Research: Brushed Block Copolymer Micelles with pH-Sensitive Pendant Groups for Controlled Drug Delivery

Type: Original PaperPurposeTo investigate the effects of small aliphatic pendent groups conjugated through an acid-sensitive linker to the core of brushed block copolymer micelles on particle properti...

Using DNA to Make Your Polymers. No Enzymes Needed.

Here's an ingenious use for DNA that never would have occurred to me. David Liu and co-workers have been using DNA-templated reactions for some time, though, so it's the sort of thing that would have...

Synthesis of novel indole hydrazone derivatives and evaluation of their antiplatelet aggregation activity.

Based on the existing reports regarding the antiplatelet aggregation activity of hydrazone derivatives, a series of indole hydrazone derivatives were considered as potential antiplatelet agents and sy...

Complexes of functionally modified hydrazone ligands-square, rectangular (M(4)), trigonal bipyramidal (M(5)) and pin-wheel (M(6)) motifs.

Hydrazone ligands modified with benzothiazole and oxime groups produce spin-coupled tetra- (Mn, Ni, Cu), penta- (Co), and hexanuclear (Cu) self-assembled clusters.

Synthesis and solid state structure of a hydrazone-disulfide macrocycle and its dynamic covalent ring-opening under acidic and basic conditions.

The synthesis and characterisation, including solid state structure, of a macrocycle containing both a hydrazone and a disulfide linkage is described. Selective ring-opening of the macrocycle under th...

Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone.

PURPOSE: To develop polymer micelles for the tunable release of Dexamethasone (DEX) in tumors. METHODS: DEX was conjugated to poly(ethylene glycol)-poly(aspartate) block copolymers using hydrazone, es...

Air-stable, narrow-band-gap ambipolar c(60) fullerene-hydrazone hybrid materials.

Fullerene-hydrazone dyads have been synthesized using the Confalone reaction followed by condensation with phenylhydrazines. Room-temperature xerographic time-of-flight, ionization potential, and cycl...