Asthma

Neurotrophic Growth Factors NGF BDNF CNTF

Early clinical trials with classical neurotrophic growth factor proteins such as NGF, BDNF, CNTF have failed for various reasons including safety, efficacy and convenience of administration as well as...

Aspirinsensitive asthma

Occupational Asthma

phosphatidylinositol 3 kinase PI3K AKT mTOR Inhibitors

The phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in the regulation of cellular growth, survival, and proliferation. Dysregula...

Epigenetic inheritance of a cocaine-resistance phenotype

In this study, the authors show that self-administration of cocaine by males resulted in an increase in BDNF expression in the mPFC and reduced drug-seeking behavior by their male offspring. This chan...

PTSD risk is associated with BDNF Val66Met and BDNF overexpression

Gene Tied to Obesity, Depression, ADHD

TUESDAY, Oct. 9 -- Researchers have identified a genetic mutation that is linked to mental illness and obesity. The researchers found that deletion of brain-derived neurotrophic factor (BDNF) is assoc...

Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation

The positive effect of stress on memory formation involves glucocorticoid receptors, but is otherwise not well understood. This article reports that stressful memory consolidation in rats involves the...

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

Synaptic dysfunction is a key pathophysiological hallmark in several neurodegenerative disorders. In this Review, Lu and colleagues consider a 'synaptic repair'-based therapy for neurodegenerative dis...

Seeking Better Understanding Of Depression

Connecting the dots between two molecules whose levels are decreased in depression and increased by current antidepressants could yield new therapies, researchers say. Serotonin is a neurotransmitter...

BDNF molecule appears to play a direct role in regulation of blood pressure

Researchers at Oregon Health & Science University's School of Dentistry have made an important connection between a molecule critical to nerve cells and high blood pressure. Production of the molecule...

Morphine inhibits BDNF protein, whereas cocaine enhances BDNF

Chronic morphine exposure has the opposite effect on the brain compared to cocaine in mice, providing new insight into the basis of opiate addiction, according to Mount Sinai School of Medicine resear...

Brain derived neurotrophic factor induces proliferation of human airway smooth muscle cells.

Airway diseases such as asthma involve increased airway smooth muscle (ASM) contractility and remodeling via enhanced proliferation. Neurotrophins (NTs) such as brain derived neurotrophic factor (BDNF...

BDNF, produced by a TPO-stimulated megakaryocytic cell line, regulates autocrine proliferation.

While human platelets release endogenous brain-derived neurotrophic factor (BDNF) upon activation, a previous report on MEG-01, a megakaryocytic cell line, found no trace of BDNF production, and the p...

BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects.

A putative pathway by which the BDNF Val66Met polymorphism (rs6265) leads to aberrant phenotypes is its influence on plasma BDNF. Research into the impact of rs6265 on plasma BDNF has given rise to co...

Diurnal variation and gender differences of plasma brain-derived neurotrophic factor in healthy human subjects.

Diurnal changes of brain-derived neurotrophic factor (BDNF) mRNA and protein contents have been demonstrated in the rat central nervous system. In humans, however, insufficient data are available on d...

Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.

Adult rats were treated acutely with peripheral kainic acid (KA), and changes in brain-derived neurotrophic factor (BDNF) mRNA and protein were tracked over time across multiple brain regions. Despite...