Vasodilators

Vasodilation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins....

Significance of estimated salt excretion as a possible predictor of the efficacy of concomitant angiotensin receptor blocker (ARB) and low-dose thiazide in patients with ARB resistance

Two Thiazide Diuretics Similar for BP Control (CME/CE)

(MedPage Today) -- For older adults with uncomplicated hypertension, neither chlorthalidone nor hydrochlorothiazide had a clear advantage over the other for preventing major adverse events, a retrospe...

Diuretics Benefit HTN Patients More With Night-Time Dosing

Should patients take thiazide diuretics at night? Therapeutic Advances in Drug Safety

Cardiovascular endocrinology: Tailoring antihypertensive drug treatment to body size

A study in patients with hypertension suggests that thiazide diuretic treatment provides less cardiovascular protection in patients of normal weight than in those with obesity, whereas a calcium chann...

[Articles] Effects of body size and hypertension treatments on cardiovascular event rates: subanalysis of the ACCOMPLISH randomised controlled trial

Hypertension in normal weight and obese patients might be mediated by different mechanisms. Thiazide-based treatment gives less cardiovascular protection in normal weight than obese patients, but amlo...

Defining Diastolic Heart Failure and Identifying Effective Therapies Defining and Treating Diastolic Heart Failure

In this issue of JAMA, Edelmann and colleagues report the results of the first substantial randomized, placebo-controlled study investigating the effects of a mineralocorticoid antagonist (MRA), spiro...

Par Formulations (Formerly Edict Pharmaceuticals) Receives First ANDA Approval

WOODCLIFF LAKE, N.J., July 13, 2012 /PRNewswire/ -- Par Pharmaceutical Companies, Inc. (NYSE: PRX) today announced that its operating subsidiary, Par Formulations Private Limited, (formerly Edict...

Approval for Manufacturing and Marketing of "Micamlo® Combination Tablets BP," an Antihypertensive Drug

- The first combination drug of a high-dose ARB and a long acting CCB with a powerful antihypertensive effect lasting for 24 hours in Japan - Tokyo, Japan, December 21, 2012 – Nippon Boehri...

Profiles of discontinuation and switching of thiazide diuretics: a cohort study among 9398 Chinese hypertensive patients.

This study tested the hypothesis that younger, male patients or new clinic visitors, who were prescribed thiazide diuretics were more likely to have drug discontinuation and switching. All adult patie...

Diuretics in the treatment of hypertension : Efficacy, safety and tolerability.

In the treatment of hypertension, both the thiazide diuretics hydrochlorothiazide and bendroflumethiazide and the "thiazide-like" diuretics chlorthalidone and indapamide are used. Guidelines refer to...

Which Diuretic Is the Preferred Agent for Treating Essential Hypertension: Hydrochlorothiazide or Chlorthalidone?

Since their introduction over 50 years ago thiazide and thiazide-like diuretics have been a mainstay in the treatment of hypertension. Yet despite outcome evidence with chlorthalidone, the prepondera...

Hydrochlorothiazide: is it a wise choice?

Introduction: Hydrochlorothiazide (HCTZ) has not been shown to reduce mortality or cardiovascular events when given as a single agent. In fact, HCTZ increased cardiovascular death and coronary artery...

The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis.

Thiazide-type diuretics are commonly used in the treatment of hypertension and nephrolithiasis. Evidence from randomized clinical trials needs to be considered in decisions about agent choice and dose...