None

High risk of kidney stones with ritonavir-boosted atazanavir for HIV

NEW YORK (Reuters Health) - There seems to be a drawback to using ritonavir-boosted atazanavir in anti-HIV regimens, Japanese investigators have found.

Lopinavir/ritonavir monotherapy effective maintenance in some HIV-infected children and adolescents

NEW YORK (Reuters Health) - Lopinavir/ritonavir (LPV/r) monotherapy provides long-term viral suppression in about 50% of children and adolescents infected with HIV, researchers say.

Pharmacokinetic Study Results Released Evaluating Interactions Between LIVALO(R) (pitavastatin) and Protease Inhibitor Combination (darunavir/ritonavir) in Healthy Volunteers

Study showed no clinically significant change in blood levels for pitavastatin or protease inhibitor combination darunavir/ritonavir when co-administered   WASHINGTON, July 22, 2012 /PRNewswire/...

HIV/AIDS Update - Kaletra (lopinavir/ritonavir) label update: drug interaction information

On January 17, 2013, FDA approved revisions to the Kaletra (lopinavir/ritonavir) labels to include new drug interaction information. The following updates were included. Anticoagulants: Rivaroxaban. A...

Lopinavir/ritonavir regulatory update

Kaletra lopinavir/ritonavir: Phase III data

Kaletra lopinavir/ritonavir: Phase II data

Gilead’s Boosting Agent Cobicistat for HIV Therapy as Effective as Ritonavir in Pivotal Phase 3 ...

Efficacy and Safety of Ritonavir Dose Reduction Based on the Tipranavir Inhibitory Quotient in HIV-Infected Patients on Salvage Antiretroviral Therapy with Tipranavir/Ritonavir.

Abstract Ritonavir-related adverse events have been reported in patients taking tipranavir/ritonavir at the licensed dosage of 500/200 mg twice daily (bid). The aim of this open-label, prospective,...

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.

PURPOSE: This study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonis...

The Antiretroviral Protease Inhibitor Ritonavir Accelerates Glutathione Export from Cultured Primary Astrocytes.

Antiretroviral protease inhibitors are a class of important drugs that are used for the treatment of human immunodeficiency virus infections. Among those compounds, ritonavir is applied frequently in...

Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin.

OBJECTIVES: Rifampicin profoundly reduces lopinavir concentrations. Doubled doses of lopinavir/ritonavir compensate for the effect of rifampicin in adults, but fail to provide adequate lopinavir conce...

Effects of the HIV Protease Inhibitor Ritonavir on GLUT4 Knock-out Mice.

HIV protease inhibitors acutely block glucose transporters (GLUTs) in vitro, and this may contribute to altered glucose homeostasis in vivo. However, several GLUT-independent mechanisms have been post...