Blast Crisis Pages on BioPortfolio:

BioPortfolio - Blast Crisis - InDepth
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in ... The B cell mutator AID promotes B lymphoid blast crisis and
drug ...
http://www.bioportfolio.com/indepth/Blast_Crisis.pdf...

BioPortfolio.com - BioWeb TAXOTERE DOCETAXEL genentechidec ...
... ongoing tumors (GIST) studies CML in blast crisis, 5/ 10/ 01 Novartis Hematologic response (chronic phase): 88% Met accelerated phase, or in
Hematologic ...
http://www.bioportfolio.co.uk/cgi-bin/dialogserver.exe?DB=se...

BioPortfolio - Blast Crisis
Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia (CML) in Accelerated Phase or Blast Phase (Blast Crisis) ...
http://www.bioportfolio.com/indepth/Blast_Crisis.html...

BioPortfolio's Rare Diseases News Feed
Blast Crisis · Blastomycosis · Blood Platelet Disorders · Bone Neoplasms · Borrelia · Botulism · Brain Neoplasms · Brain Stem Neoplasms · Brenner Tumor ...
http://www.bioportfolio.co.uk/news/rare.shtml...

Gleevec Resistance
Blast crisis is a phase of CML when cancer cells have not only the hallmark chromosomal ... In patients with blast crisis, resistance to Gleevec occurs in
...
http://www.bioportfolio.com/news/btech_041802_1.htm...

BioPortfolio's Cancer Conditions News Feed
Blast Crisis · Bone Cancer · Bone Cysts · Bone Neoplasms · Brachytherapy Radiation Therapy · Brain Cancer · Brain Neoplasms · Brain Stem Neoplasms ...
http://www.bioportfolio.co.uk/news/cancer_list.html...

BioPortfolio Limited Stakeholder Insight: Chronic Leukemias - Is ...
Percentage of patients progressing to blast crisis CML 233 ... Blast crisis is the greatest area of unmet need in CML but may not be the most commercially ...
http://www.bioportfolio.com/cgi-bin/acatalog/2119.html...

BioPortfolio - BMI1 - BMI1 polycomb ring finger oncogene
17360938, In a cohort of 64 CML patients, the level of BMI1 at diagnosis correlated with time to transformation to blast crisis, and the combination of
low ...
http://www.bioportfolio.com/gene/648-BMI1.html...

BioPortfolio - HMGA2 - high mobility group AT-hook 2
... of HMGA2 expression is correlated to the undifferentiated phenotype of leukaemic cells accumulating during progression of chronic phase to blast crisis
...
http://www.bioportfolio.com/gene/8091-HMGA2.html...

BioPortfolio - AKAP13 - A kinase (PRKA) anchor protein 13
12663445, The HA-3 peptide, VTEPGTAQY, is encoded by the lymphoid blast crisis oncogene, showing for the 1st time that a leukemia-associated oncogene can ...
http://www.bioportfolio.com/gene/11214-AKAP13.html...

Results from other life science and pharmaceutical sites:

Chronic myelogenous leukemia - Wikipedia, the free encyclopedia
Blast crisis is the final phase in the evolution of CML, and behaves like an acute leukemia, with rapid progression and short ...
http://en.wikipedia.org/wiki/Chronic_myelogenous_leukemia...

Chronic Myelocytic Leukemia (CML): Leukemias: Merck Manual Home ...
Eventually the leukemia cells undergo more changes, and the disease progresses to an accelerated phase and then inevitably to blast crisis. In blast crisis ...
http://www.merck.com/mmhe/sec14/ch176/ch176e.html...

The biology of CML blast crisis.
Although the pathogenic effects of most CML blast crisis secondary changes are still poorly understood, ample evidence suggests that the phenotype of CML ...
http://www.ncbi.nlm.nih.gov/pubmed/14982876...

Cancer Cell - Imatinib Resistance and Progression of CML to Blast ...
8 Sep 2009 ... The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia Cancer Cell, Volume 16, Issue 3, ...
http://www.cell.com/cancer-cell/abstract/S1535-6108(09)00258...

FTY720, a new alternative for treating blast crisis chronic ...
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome- positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal ...
http://www.ncbi.nlm.nih.gov/pubmed/17717597...

Bone Marrow Transplantation - Abstract of article: Lymphoid blast ...
Lymphoid blast crisis of chronic myelogenous leukemia occurring more than 11 years after receiving an allogeneic bone marrow transplant for chronic ...
http://www.nature.com/bmt/journal/v31/n3/abs/1703820a.html...

A murine model of CML blast crisis induced by cooperation between ...
Progression of CML to acute leukemia (blast crisis) in humans has been associated with acquisition of secondary chromosomal translocations, including
the ...
http://www.ncbi.nlm.nih.gov/pubmed/12032333...

Sudden Extramedullary T-Lymphoblastic Blast Crisis in CML ...
27 May 2008 ... Abstract and Introduction: Imatinib treatment of CML can produce long-term remission and improve survival in most patients, but uncommon ...
http://www.medscape.com/viewarticle/571981...

Chronic myeloid leukemia in blast crisis treated with imatinib 600 ...
DESIGN AND METHODS: We conducted a phase II trial of imatinib 600 mg daily in patients with chronic myeloid leukemia in blast crisis. The return to chronic
...
http://www.ncbi.nlm.nih.gov/pubmed/18838477...

Molecular evidence for the clonal origin of blast crisis in ...
We have used probes for the bcr gene to obtain molecular evidence for the clonal origin of blast crisis in 2 patient with CML. In both cases, the first with ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20...

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