Breast Cancer

Breast cancer in the UK is diagnosed in nearly  46,000 people  each year, with just over 12,000 dying from breast cancer each year in he UK. There are several risk factors for developing b...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...

Selective Estrogen Receptor Modulators SERMs

Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ER) agonists or antagonist depending on the targeted tissue and the specific configuration of the used SERM. Effects on bone, e...

Breast Lumps

Antibody Drug Conjugates ADC

The humanized anti-Her2 monoclonal antibody Herceptin (trastuzumab) has become the mainstay in the treatment of Her2-positive breast cancer. Combining trastuzumab with the potent cytotoxic DM1 via a s...

Density Of Breasts Does Not Impact Death Among Breast Cancer Patients

A study featured in the August 20 edition in the Journal of the National Cancer Institute reveals that the risk of mortality from breast cancer is not associated with high mammographic breast density...

Treating HER2+ Breast Cancer With HIV Drug

The HIV protease inhibitor, Nelfinavir, can be used to treat HER2-positive breast cancer in the same capacity and dosage regimen that it is used to treat HIV, according to a study published in the Jou...

Breast cancer… do you know who diagnoses you?

Australian women have a 1 in 9 lifetime risk of developing breast cancer and 1 in every 100 breast cancers occurs in men. In 2012, it is estimated that 14,610 women will be diagnosed with breast canc...

Breast augmentation may hurt breast cancer survival

The weight of evidence from epidemiological studies indicates cosmetic breast implants are not associated with increased risk of breast cancer, but concern remains because implants may impair the ab...

Breast Implants Linked to Poorer Survival From Breast Cancer

Women with breast implants who develop breast cancer have a higher risk of being diagnosed with nonlocalized breast tumors and lower breast-cancer-specific survival, but there are study limitations....

Breast cancer's many drivers

(Broad Institute of MIT and Harvard) Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast...

Breast density does not influence breast cancer death among breast cancer patients

(Journal of the National Cancer Institute) The risk of dying from breast cancer was not related to high mammographic breast density in breast cancer patients, according to a study published Aug. 20 in...

Link Identified Between Breast Size and Breast Cancer: Study

European scientists have discovered the first specific genetic link between breast size and the risk of breast cancer. They concluded that having a larger-than-average breast size while a young woman...

The risk of a second primary lung cancer after a first invasive breast cancer according to estrogen receptor status.

PURPOSE: Lung cancers account for 5 % of second primary cancers after breast cancer. The low overall 5-year relative survival rate of lung cancer makes it a particularly concerning new malignancy for...

MRI findings of inflammatory breast cancer, locally advanced breast cancer, and acute mastitis: T2-weighted images can increase the specificity of inflammatory breast cancer.

Inflammatory breast carcinoma (IBC) is rare; however, it is the most aggressive variant of breast cancer with a very poor outcome. Locally advanced breast cancer and acute mastitis have a presentation...

Mammographic breast density and breast cancer risk by menopausal status, postmenopausal hormone use and a family history of breast cancer.

PURPOSE: Few studies have investigated the association between breast density and breast cancer by a family history of breast cancer, menopausal status, and postmenopausal hormone use (PMH). We invest...

Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer.

ABSTRACT: BACKGROUND: The association between lobular breast cancer and family history is not clear. The aim of the study was to possibly identifying new hereditary patterns predisposing for cancer i...

Leptin and breast cancer: an overview.

Leptin is a well-known mediator of obesity. Leptin and its receptor are overexpressed in breast cancer, especially in high-grade tumors. It has an association with progression and poor survival of bre...