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Bumetanide could treat children with severe autism or Asperger's syndrome

Although this therapy is not curative, it nevertheless reduced the autistic disorders' severity in three-quarters of the children. The researchers have filed a request for authorisation to perform a m...

Comparison Of 3 Water Pills For Heart Failure Finds The Most Effective May Be The Least Prescribed

Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until Yale School of Medicine...

New York Times offers tragic cautionary tale about nutritional supplements

Last weekend’s New York Times offers yet another cautionary tale about the health risks associated with nutritional supplements. This time the focus is on a popular workout supplement called Jack3d,...

Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis.

OBJECTIVE: To test the hypothesis that inhibition of the Na-K-2Cl transporter with bumetanide will reduce the susceptibility to decreases in muscle force in a mouse model of hypokalemic periodic paral...

Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca(2+) Thus Facilitating Intermediate Conductance Ca (2+)-Activated Potassium Channels.

Loop diuretics such as bumetanide and furosemide enhance aminoglycoside ototoxicity when co-administered to patients and animal models. The underlying mechanism(s) is poorly understood. We investigate...

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits.

A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to hypersyncrhonous activity. During development, gamma-aminobutyric acid (GABA...

Individualization of a pharmacokinetic model by fractional and nonlinear fit improvement.

This study presents application of a new linear and nonlinear fractional derivative two compartmental model to the evaluation of individual pharmacokinetics. In the model, the integer order derivative...

Ammonium influx pathways into astrocytes and neurones of hippocampal slices.

Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonemic conditions, increases in the cellular influx of...