Search Results for "Buprenorphine Pipeline"
Original Source: Acute effects of sublingual buprenorphine on brain responses to heroin-related cues in early-abstinent heroin addicts: an uncontrolled trial.
Replacement therapy with buprenorphine is clinically effective in reducing withdrawal and craving for heroin during detoxification but not in decreasing the probability of relapse after detoxification. This study examined the acute effects of buprenorphine on brain responses to heroin-related cues to reveal the neurobiological and therapeutic mechanisms of addiction and relapse. Fifteen heroin addicts at a very early period of abstinence, were studied in two separate periods 10-15 min apart: an early period...
Matching Channels
Human Epidermal Growth Factor receptor EGF R
The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...
Tumor Necrosis Factor TNF Products
Tumor Necrosis Factor (TNF) and TNF receptor antagonists and agonists used to treat TNF-mediated inflammatory diseases such as rheumatoid arthritis or to treat cancer. TNF blockers are the commerc...
The Scandinavian country of Norway hosts a leading biotechnology industry. In 2009 a $418m stimulus package was established for the industry, to ensure it could continue to grow and ride out the fin...
Fourteen different blood coagulation factors are present in the body. Each plays a crucial role in the process described above. Some work to increase the activity level of the other factors while so...
Respiratory syncytial virus RSV Vaccines
Respiratory syncytial virus (RSV) infection, which manifests primarily as bronchiolitis and/or viral pneumonia, is the leading cause of lower respiratory tract infection in infants and young children....
Matching News
Significant Rise In Emergency Department Visits Related To Buprenorphine Use
There has been a significant increase in the number of emergency department visits related to the drug buprenorphine, a medicine used to treat opioid addiction. The number of emergency visits due to b...
Benzodiazepines Plus Buprenorphine Linked to ED Visits
Patients receiving buprenorphine treatment who are also receiving prescriptions for benzodiazepines have more visits to the emergency department than those without a benzodiazepine Rx. Medscape Medi...
Liver Toxicity Fears With Buprenorphine, Methadone Allayed
Concerns that treatment with buprenorphine or methadone might be toxic to the liver have been allayed, with a phase IV study showing no evidence that either drug harms the liver. Medscape Medical Ne...
Orexo AB (SSE:ORX) said FDA accepted for review an NDA for Zubsolv buprenorphine/naloxone to treat opioid dependence. The PDUFA date is July 6, 2013. The application was submitted under section 505(b)...
FDA panel to discuss Titan's Probuphine
FDA's Psychopharmacologic Drugs Advisory Committee will meet on March 21 to discuss an NDA for Probuphine buprenorphine from Titan Pharmaceuticals Inc. (OTCBB:TTNP) to treat opioid dependence. The PDU...
FDA reviewers question Probuphine efficacy, safety
Titan Pharmaceuticals Inc. (OTCBB:TTNP) fell $0.85 (42%) to $1.19 on Tuesday after FDA reviewers questioned the efficacy and safety of Probuphine buprenorphine to treat opioid dependence. In briefing...
Titan Pharma: Run-Up Trade Into March FDA Panel
NEW YORK (TheStreet) -- Titan Pharmaceuticals is developing Probuphine, a proprietary, long-acting form of the opioid dependence drug buprenorphine. Probuphine is implanted just under the skin of the...
Accidental exposure to buprenorphine can make children extremely sick
Buprenorphine is a safe and effective drug for treating opioid addiction. But as the prescribed use of buprenorphine has dramatically increased in recent years, accidental exposure of children to the...
Matching PubMed Articles
Buprenorphine (Subutex) and buprenorphine/naloxone (Suboxone) received Food and Drug Administration approval in 2002 for the treatment of opioid dependence. Introduction of these drugs expanded the av...
Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine.
The unique pharmacological profile of buprenorphine has led to its considerable success as an analgesic and as a treatment agent for drug abuse. Activation of nociceptin/orphanin FQ peptide (NOP) rece...
The SUMMIT Trial: A field comparison of buprenorphine versus methadone maintenance treatment.
This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs. A total of 3...
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects.
Previous reports have demonstrated greater antinociception following administration of a buprenorphine/naloxone combination compared to buprenorphine alone among healthy volunteers. The aim of the cur...
Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats.
Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats....
