Lupus Nephritis

Systemic lupus erythematosus

Lupus is a systemic autoimmune disease that can affect any part of the body. As with other autoimmune diseases, the immune system attacks the body’s cells and tissue resulting in inflammation...

Variant Forms of Lupus

Discoid lupus erythematosus DLE

Discoid lupus erythematosus (DLE) is a disease of the skin causing atrophy, scarring and photosensitivity. DLE affects between 17 and 48 per 100,000 people, occuring twice as often in women. The cha...

Systemic Lupus Erythematosus SLE

Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. Because the antibodies and accompanying cells of inflammation can affect tissues anywhe...

Researchers develop unique approach to calpain inhibition

Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in muscular dystrophy, A...

Penn team developing new class of malaria drugs using essential calcium enzyme

(University of Pennsylvania School of Medicine) Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state, and has bee...

World Lupus Day: Lupus organizations to rally together to raise awareness of lupus

The Lupus Foundation of America and lupus organizations around the globe are rallying together on May 10, World Lupus Day, to urge action and raise awareness of lupus, a mysterious and devastating dis...

Lupus Treatment | How “Lupus Bible” Helps People Get Rid Of Lupus Condition Permanently – Tony Nguyen

Seattle, Wa (PRWEB) March 08, 2013 Lupus Bible is the new achievement of Julia Liu, who claims to give people the lupus treatment to help them get rid of their lupus disease permanently and natur...

Barriers to overcome in lupus drug development

It has taken the lupus research community over 50 years to produce a new therapy. Although it is now a year old, Benlysta (belimumab), now marketed by GlaxoSmithKline and Human Genome Sciences, is the...

Lupus Research Institute awards first $1M private sector grants to uncover lupus causes

(Lupus Research Institute) The Lupus Research Institute announced the first $1 million privately funded research grants given to lupus investigators. The LRI Distinguished Innovator Initiative was cr...

Michigan Lupus Foundation: New Name, Same Great Services

St. Clair Shores, Michigan (PRWEB) December 13, 2012 The Michigan Lupus Foundation represents the over 85,000 Lupus Warriors in Michigan and northern Indiana, and is the only nonprofit organization...

Lupus Research Institute Co-Hosts Lupus Congressional Briefing to Highlight Serious Unmet Needs in Lupus

NEW YORK, July 11, 2012 (GLOBE NEWSWIRE) -- The Lupus Research Institute (LRI) joined with members of the U.S. Congressional Lupus Caucus and other lupus community partners in sponsoring a Congressio...

Mitochondrial calpain 10 is degraded by Lon protease after oxidant injury.

Calpain 10 is ubiquitously expressed and is one of four mitochondrial matrix proteases. We determined that over-expression or knock-down of mitochondrial calpain 10 results in cell death, demonstratin...

Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2.

Important to the function of calpains is temporal and spatial regulation of their proteolytic activity. Here, we demonstrate that cytoplasm-resident calpain 2 cleaves human nuclear topoisomerase I (hT...

Loss of calpain 10 causes mitochondrial dysfunction during chronic hyperglycemia.

We showed that renal calpain 10, a mitochondrial and cytosolic Ca(2+)-regulated cysteine protease, is specifically decreased in kidneys of diabetic rats and mice, and is associated with diabetic nephr...

M-calpain activation is regulated by its membrane localization and by its binding to PIP2.

M-calpain plays a critical role in cell migration. Growth factors and chemokines regulate keratinocyte, fibroblast and endothelial cell migration by modulating m-calpain activity. Growth factor recept...

Effects of Inhibitors on the Synergistic Interaction between Calpain and Caspase-3 during Post-mortem Aging of Chicken Meat.

Calpain has been considered to be the most important protease involved in tenderization during the conversion of muscle into meat. However, recent evidence suggests the possible involvement of the key...