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Trials of Drugs for Prehypertension: Too Little, Too Late?

Experts gathered at the International Conference on Prehypertension and Cardiometabolic Syndrome say they can't wait for the data from ongoing clinical trials--they are proceeding with low-dose pharma...

Higher heart risk with diclofenac than other NSAIDs

Diclofenac is associated with a "consistent but small" increase in the risk of cardiovascular side effects...

AAPS PharmSciTech: Simultaneous Determination of EDTA, Sorbic Acid, and Diclofenac Sodium in Pharmaceutical Preparations Using High-Performance Liquid Chromatography

Type: Original PaperA simple high-performance liquid chromatographic method for simultaneous determination of ethylenediaminetetraacetic acid (EDTA), sorbic acid, and diclofenac sodium was developed a...

Acute Pain Yields to Lower-Dose Diclofenac

(MedPage Today) -- FORT LAUDERDALE, Fla. - Lower-dose submicron particle diclofenac offered good pain control compared with placebo, researchers reported here.

Diclofenac and CVD Risks

Diclofenac, which is listed on the essential-medicine lists of 74 countries, increased the risk of cardiovascular events between 38% and 63% in different studies. The increased risk with diclofenac wa...

Global use of diclofenac widespread, despite CV risks

Diclofenac use remains widespread globally despite the drug’s known cardiovascular risks, a study in PLOS Medicine has shown (online 12 February 2013). Researchers looked at cardiovascular risk...

Drug being 'overprescribed'

An international study has suggested that a painkiller that increases the risk of heart attack and stroke may be being overprescribed. Prescribing practices were examined in 15 countries, includi...

Iroko reports Phase III data for submicron diclofenac

Iroko Pharmaceuticals LLC (Philadelphia, Pa.) said thrice-daily lower dose submicron diclofenac met the primary endpoint of reducing mean WOMAC pain subscale scores from baseline to week 12 vs. placeb...

Prevalence and Risk Factors Associated with Prehypertension and Hypertension in the Chinese She Population.

Background: Little is known about the prevalence and cardiovascular risk factors for prehypertension and hypertension in the She ethnic minority population of Fujian province in China. Methods and Res...

Epidemiology of Prehypertension and Associated Risk Factors in Urban Adults From 33 Communities in China.

Background: The Seventh Report of The Joint National Committee has recently introduced the prehypertension category of blood pressure (BP) status that needs monitoring and intervention. Little is know...

Associations of cardiovascular risk factors with prehypertension and hypertension in women.

The purpose of this study was to clarify the relationships of cardiovascular risk factors with prehypertension and hypertension in women. Japanese women (35-54 years old, n = 9939) were divided by blo...

Gender-specific prevalence and associated risk factors of prehypertension among rural children and adolescents in Northeast China: a cross-sectional study.

Little is known about the prevalence and risk profile of prehypertension among Chinese children and adolescents. The aim of the present study was to investigate the prehypertensive status and its asso...

High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China.

ABSTRACT: BACKGROUND: Prehypertension and prediabetes are major risk factors of cardiovascular disease, and their combined presence may result in more serious cardiovascular outcomes than expected wi...