Toxicity

Vitamin A Toxicity

Vitamin B6 Toxicity

Niacin Toxicity

Vitamin D Toxicity

Glucarpidase for Methotrexate Toxicity Oncologic Emergency

Cancer patients on high-dose methotrexate who develop renal impairment and acute toxicity can be rescued with a single dose of the new agent. Medscape Medical News

A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice

Hamner debuts toxicity testing initiative

The Hamner Institutes for Health Sciences announced a partnership focused on toxicity testing research. The not-for-profit and Brown University will develop human cell-based assays that map and model...

New Single Loading Dose Option For VIMPAT® (Lacosamide) In The EU Allows For Rapid Initiation Of Adjunctive Treatment Of Partial Onset Seizures

All formulations of VIMPAT® (lacosamide) approved in the European Union for initiation as a single loading dose (200 mg) followed by a daily maintenance dose regimen1 UCB announced this week that VIM...

FDA: Label change for single IV dose of ondansetron

FDA is alerting healthcare professionals to the possibility that a 32-mg single intravenous dose of ondansetron (Zofran, ondansetron hydrochloride, and generics) could lead to QT interval prolonga...

Single, fractional dose of polio vaccine induces priming

(HealthDay)—Priming immune responses are induced in most infants after vaccination with a single dose of inactivated poliovirus vaccine (IPV), according to a study published in the Jan. 31 issue of...

South Africa rolls out new single dose AIDS drug

South Africa's health minister on Monday launched a new single dose anti-AIDs drug which will simplify the world's biggest HIV treatment regime to just one life-saving pill a day.

Single dose of seasonal flu vaccine is safe for egg allergic children

Egg allergic children, including those with a history of anaphylaxis to egg, can safely receive a single dose of the seasonal influenza vaccine, according to a new study from the University of Michiga...

Evaluation of safety of the herbal formula Ojeok-san: Acute and sub-chronic toxicity studies in rats.

AIM OF THE STUDY: :Ojeok-san (OJS; wuji powder in China and goshaku-san in Japan), a widely used herbal formula in traditional Korean medicine and Japanese herbal medicine (Kampo medicine), has been u...

Isolated limb infusion with hyperthermia and chemotherapy for advanced limb malignancy: factors influencing toxicity.

BACKGROUND: The isolated limb infusion (ILI) technique is a simpler and less invasive alternative to isolated limb perfusion, which allows regional administration of high-dose chemotherapy to patients...

Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy.

ABSTRACT: BACKGROUND: In early-phase studies with targeted therapeutics and radiotherapy, it may be difficult to decide whether an adverse event should be considered a dose-limiting toxicity (DLT) of...

Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors.

Objective: The purpose of this study was to investigate the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics of ursolic acid liposomes (UAL), as a new drug, in healthy...

The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man.

At present, regulatory assessment of systemic toxicity is almost solely performed using animal models. The EU REACH legislation stimulates the use of animal-free approaches to obtain information on th...