Search Results for "Children With Chromosome 20q11 Duplication"
Original Source: The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion.
Deletion of the long arm of one chromosome 20 (del(20q)) is a well-recognized abnormality in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and is presumed to cause loss of a tumor suppressor gene at 20q12. In a previously published series of MDS and AML cases, which had lost this region via unbalanced translocation, around 40% of cases were shown to have additional copies of the chromosome 20 abnormalities, with resulting gain or amplification of the retained parts of chromosome 20, most...
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Hypopituitarism in Children Resulting in Short Stature
What is GENOTROPIN? GENOTROPIN (somatropin [rDNA origin] for injection) is a growth hormone treatment. It is an exact copy of the natural growth hormone that our bodies make. The main difference i...
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Genetic Connections Identified In 15q Duplication Syndrome/Autism
A new study published in the March issue of Autism Research from the University of Tennessee Health Science Center and Le Bonheur researchers is making the genetic connections between autism and Chrom...
Results from a new study are providing significant insights into autism through the study of a specific form of the disorder caused by a duplication on chromosome 15.
Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation
iceFISH labels nascent RNA along a single chromosome, revealing chromosome territories and potential regulatory mechanisms working at the chromosome scale.
Research yields significant insights into a common form of autism
(Le Bonheur Children's Hospital) Results from a study led by Larry T. Reiter, PhD, at the University of Tennessee Health Science Center are providing significant insights into autism through the study...
Our results suggests that imatinib in conjunction with intensive chemotherapy is well tolerated and might be beneficial for treatment of children with Philadelphia-chromosome-positive ALL.
Study examines specific form of autism caused by duplication on chromosome 15
Identifying and understanding the combination of factors that leads to autism is an ongoing scientific challenge. This developmental disorder appears in the first three years of life, and affects the...
Pediatric imatinib for Philadelphia-chromosome ALL fights relapse
Trial findings confirm the benefits of imatinib therapy in children with Philadelphia-chromosome-positive acute lymphoblastic leukemia.
Matching PubMed Articles
Deletion of the long arm of one chromosome 20 (del(20q)) is a well-recognized abnormality in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) and is presumed to cause loss of a tumor s...
Direct duplication of the Y chromosome with normal phenotype - incidental finding in two cases.
Structural rearrangement in the Y chromosome is closely involved in spermatogenesis. However, several Y chromosome variants may have no deleterious effects on male reproduction. Here, we report two ca...
Cytogenetics of hepatoblastoma.
The cytogenetics of hepatoblastoma demonstrate recurring events which include whole chromosome trisomies, most commonly trisomy of chromosome 2, 8, or 10. In addition, unbalanced translocations involv...
The incidence of therapy-related myelodysplastic syndrome (t-MDS) in pediatric patients is increasing in parallel with the more successful management of the primary tumor, but scant information is ava...
Proper assembly and function of a bipolar mitotic spindle is crucial for faithful bidirectional chromosome segregation during cell division. In animal cells, the two poles of the mitotic spindle are o...
