Selective monoamine oxidase type B MAOB inhibitors

The clinical benefit of monoamine oxidase type B (MAO-B) inhibitors is thought to arise from an ability of these medications to enhance the level of dopamine by decreasing the catabolism. Additional...

Excipients Top List of Hot Topics at The Bioavailability Challenge

Formulators still think of excipients first when faced with drug bioavailability difficulties judging by trends that emerged at our online event.

Dow Signs Up Cambrex for Bioavailability Partnership

Dow has contracted Cambrex to make its solubility enhancing polymer HPMCAS, adding manufacturing clout to its bioavailability-focused collaboration with Bend Research.

Chinese CRO Partnerships Focus on Bioavailability, PK/PD Analysis

Contract drug developer Particle Sciences has recently chosen China-based CRO Crystal Pharmatech to analyse the bioavailability and material properties of its developing compounds, and the collaborati...

Battling Bioavailability? Find Your Solubility Solution at BAC 2013!

Drug solubility science, technology and solutions will take centre stage at “The Bioavailability Challenge” a free to attend online event in-Pharmatechnologist.com is hosting on Wednesday, March...

Bioavailability Concerns Drive Interest From Supplements Toward Foods

The supplement industry appears “a little bit asleep at the switch” as consumer concerns about bioavailability push them away from vitamins and minerals toward whole food nutrition, market analyst...

Merck Millipore to open new bioavailability lab in 2013

The bioavailability market lacks a leader that can offer comprehensive solutions according to Merck Millipore, which has set its sights on filling the gap through investments and a new lab.

Hovione and Solvias form industry's latest bioavailability-focused accord

Hovione and Solvias have become the latest suppliers to team on drug solubility and bioavailability services in a new deal announced today.

Liposomes Expand Cancer Drug's Bioavailability and Potency in Mouse Model

Encapsulation of the anticancer drug doxorubicin within PEGylated liposomes increased the compound's intracranial tumor bioavailability, extended its lifetime in circulation,...

The association between nC(60) and 17α-ethinylestradiol (EE2) decreases EE2 bioavailability in zebrafish and alters nanoaggregate characteristics.

Abstract Manufactured nanoparticles (NPs) released into surface waters will associate with other substances and these interactions may affect environmental fate and bioavailability of NPs and the asso...

Pharmacokinetics of pterostilbene in Sprague-Dawley rats: The impacts of aqueous solubility, fasting, dose escalation, and dosing route on bioavailability.

SCOPE: Pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene, PTS) possesses various health-promoting effects. This study aimed to investigate the impacts of aqueous solubility, fasting, dose escalati...

Effect of genetic polymorphisms of SLC28A1, ABCG2, and ABCC4 on bioavailability of mizoribine in healthy Japanese males.

The aim of the present study was to investigate the genetic factors responsible for the interindividual variability in bioavailability of mizoribine. Thirty healthy Japanese males, aged 20-49 years ol...

Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils.

Background: Assessment of soil arsenic bioavailability may profoundly affect the extent of remediation required at contaminated sites by improving human exposure estimates. Because small adjustments i...

Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine-based formulation.

Abstract Objective: Methylnaltrexone (MNTX), a peripherally restricted opioid antagonist with mu-opioid receptor selectivity, can reduce opioid activity in the gastrointestinal tract while sparing the...