Regulatory Mechanisms

Regulatory factors

Gastrointestinal Effects

RPL554

Verona’s lead drug, RPL554, is a dual phosphodiesterase (PDE) 3 and 4 inhibitor being developed as a novel treatment for chronic obstructive airways disease as COPD (chronic obstructive pulmon...

Adverse drug effects

Mapping cis- and trans-regulatory effects across multiple tissues in twins

The MuTHER Consortium reports an analysis of the genetics of gene expression in three tissues from approximately 850 mono- and dizygotic twins. They systematically dissect cis and trans genetic effect...

Understanding and prevention of side effects caused by drugs

Yellow vision, pseudo-pulmonary obstruction, involuntary body movements, respiratory paralysis. These are some of the 1,600 known side effects (SEs) produced by drugs. Adverse effects are one of the m...

Dissociating the effects of A2A agonism

Researchers in Germany have dissociated the anti-inflammatory effects of adenosine A2A receptor agonists from their hemodynamic effects and are determining a specific inflammation-related indication t...

Study Contributes To The Understanding And Prevention Of The Side Effects Caused By Drugs

Yellow vision, pseudo-pulmonary obstruction, involuntary body movements, respiratory paralysis. These are some of the 1,600 known side effects (SEs) produced by drugs. Adverse effects are one of the m...

The Return of CB1

CB1 ligands were all the rage a few years ago, headlined by Sanofi's rimonabant. These looked like the best shot at the obesity market in a long time, if you were of an optimistic frame of mind. But t...

PRS launches Global Regulatory Intelligence Database

Pharmaceutical Regulatory Services, Inc., a global provider of regulatory and pharmacovigilance support to the pharmaceutical, biotechnology and medical device industries, is pleased to announce the l...

Close to the bone: metabolic effects of glucocorticoids

Long-term glucocorticoid treatment is associated with many dangerous side effects, including weight gain, insulin resistance, diabetes, and osteoporosis; however, the pathological mechanisms that caus...

Thomson Reuters unveils new regulatory intelligence solution at DIA 2012

The Intellectual Property & Science division of Thomson Reuters unveiled Cortellis for Regulatory Intelligence™ at the DIA 2012 Annual Meeting in Philadelphia today. This new offering is the next ge...

Effects of cis-regulatory variation differ across regions of the adult human brain.

Cis-regulatory variation is considered to be an important determinant of human phenotypic variability, including susceptibility to complex disease. Recent studies have shown that the effects of cis-re...

Regulatory Network Operations in the Pathway Tools Software.

ABSTRACT: BACKGROUND: Biologists are elucidating complex collections of genetic regulatory data for multiple organisms. Software is needed for such regulatory network data. RESULTS: The Pathway Tools...

Selection and constraint on regulatory elements in Drosophila simulans.

We utilized available Drosophila simulans molecular population genomic data to characterize sequence polymorphism in noncoding regulatory regions and their corresponding transcribed target genes or in...

Targeting myeloid regulatory cells in cancer by chemotherapeutic agents.

Recent findings in humans and numerous experimental models provide evidence of the important role of immune regulatory cells in cancer and various diseases. "Myeloid regulatory cells" (MRC) include my...

When do chronic differences in self-regulation count?: regulatory focus effects in easy and difficult soccer tasks.

Research on regulatory focus theory (Higgins, 1997) suggests that performance increases if instructions fit with sportspersons' dispositions. Sportspersons who chronically focus on wins (i.e., promoti...