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FDA Drug Safety Communication: Revised recommendations for Celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses

The U.S. Food and Drug Administration (FDA) is clarifying dosing and warning recommendations for the antidepressant Celexa (citalopram hydrobromide; also available in generic form).

Pending EC decision: Nuedexta, dextromethorphan hydrobromide/quinidine sulfate, Opinion date: 25-Apr-2013

Pending EC decision: Nuedexta, dextromethorphan hydrobromide / quinidine sulfate, Opinion date: 25-Apr-2013

Tanabe Mitsubishi Applies For DPP-4 Inhibitor Tenelia Combination Therapy

Tanabe Mitsubishi has applied for an additional indication for DPP-4 inhibitor 20mg Tenelia tablets (teneligliptin hydrobromide hydrate) for use in combination therapy, the company announced on Feb. 2...

CHMP recommends approval of NUEDEXTA for treatment of pseudobulbar affect

Avanir Pharmaceuticals, Inc. today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion for NUEDEXTA (dextromethorphan hydr...

Concert Pharmaceuticals Announces Milestone Achievement in Avanir Pharmaceuticals Collaboration

Concert Pharmaceuticals, Inc. today announced that it has achieved a milestone under its licensing agreement with Avanir Pharmaceuticals, Inc. for the development of AVP-786 (also...

Avanir Pharmaceuticals Announces Patient Assistance Program For NUEDEXTA

ALISO VIEJO, Calif., June 5, 2012 /PRNewswire/ -- Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR) today announced details of its Patient Assistance Program for NUEDEXTA® (dextromethorphan...

Avanir Pharmaceuticals Announces Positive Interim Data From Pharmacokinetic Study With Next Generation Compound AVP-786

ALISO VIEJO, Calif., Feb. 7, 2013 /PRNewswire/ -- Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR) announced today that it has successfully completed the first of a two-stage pharmacokinetic study wit...

Synthesis of fused indazole ring systems and application to nigeglanine hydrobromide.

The single-step synthesis of fused tricyclic pyridazino[1,2-a]indazolium ring systems is described. Structural details revealed by crystallography explain the unexpected reactivity. The method is appl...

Identification and structural elucidation of two process impurities and stress degradants in darifenacin hydrobromide active pharmaceutical ingredient by LC-ESI/MS(n).

The present study describes the identification and characterization of two process impurities and major stress degradants in darifenacin hydrobromide using high performance liquid chromatography (HPLC...

Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics.

A simple and high sensitive technique based on three phase hollow fiber liquid phase microextraction (HF-LPME), optimized by using a four-variable experimental design and response surface methodology...

Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology.

The objective of this study is to develop and in vivo evaluation of novel monolithic matrix mini tablets approach to control the release of galantamine hydrobromide (GAH) in comparison with desired re...

Floating matrix dosage form for dextromethorphan hydrobromide based on gas forming technique: in vitro and in vivo evaluation in healthy volunteers.

The objective of this study was to develop the dextromethorphan hydrobromide sustained-release (DMB-SR) tablets using floating technique to prolong the gastric residence time and compared their pharma...