Search Results for "Ckd Urate"
Original Source: Challenges of conducting a trial of uric-acid-lowering therapy in CKD.
Observational studies have shown that asymptomatic hyperuricemia is associated with increased risks of hypertension, chronic kidney disease (CKD), end-stage renal disease, cardiovascular events, and mortality. Whether these factors represent cause, consequence or incidental associations, however, remains uncertain. Hyperuricemia could be a consequence of impaired kidney function, diuretic therapy or oxidative stress, such that elevated serum urate level represents a marker, rather than a cause, of CKD. On t...
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Köttgen and colleagues report genome-wide association studies for serum urate in over 140,000 individuals from the Global Urate Genetics Consortium (GUGC). They identify 18 loci newly associated...
Study supports urate protection against Parkinson's disease, hints at novel mechanism
(Massachusetts General Hospital) Use of the antioxidant urate to protect against the neurodegeneration caused by Parkinson's disease appears to rely on more than urate's ability to protect against oxi...
Genetic manipulation of urate alters neurodegeneration in mouse model of Parkinson's disease
A study by Massachusetts General Hospital researchers adds further support to the possibility that increasing levels of the antioxidant urate may protect against Parkinson's disease. In their report p...
Vitamin C supplements 'do not lower uric acid levels in people with gout'
Vitamin C supplementation does not have a clinically significant effect on uric acid (urate) levels in people with gout, a study has found.Researchers at the University of Otago in New Zealand assesse...
Research reveals vitamin C does not reduce urate levels in gout patients
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significan...
A young mother attends the surgery concerned about blood in her 7 month old daughter’s nappy.What you should coverWas it blood?Urinary urate crystals can stain the nappy red, but this is not...
Gout 'common' among patients with kidney disease
Gout is common among people with chronic kidney disease and becomes increasingly prevalent as the severity of kidney disease rises, a new study has shown.About 1.4 per cent of adults in the UK are aff...
Crystal arthritis: A new 'package of care' strategy for effective gout management
Gout is often poorly managed, with low rates of successful long-term urate lowering. A new 'package of care' intervention for treatment of patients with gout now offers ways to improve outcomes. The i...
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The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults.
Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly commun...
An exploratory study of serum urate levels in patients with amyotrophic lateral sclerosis.
Urate is a natural antioxidant, and high serum urate levels could be protective against the development of amyotrophic lateral sclerosis (ALS). To determine if serum urate concentrations were lower in...
Urate Is a Ligand for the Transcriptional Regulator PecS.
PecS is a member of the MarR (multiple antibiotic resistance regulator) family, which has been shown in Erwinia to regulate the expression of virulence genes. MarR homologs typically bind a small mole...
There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to the degeneration of dopaminergic neurons. Recent research has shown that higher blood ura...
Plasma Urate and Parkinson's Disease in Women.
Plasma urate has been consistently associated with a lower risk of Parkinson's disease in men, but it is less clear if this relation exists in women. Between 1990 and 2004, the authors conducted a nes...
