Search Results for "Cleavable Biotin"
Original Source: Cleavable Biotin Probes for Labeling of Biomolecules via Azide-Alkyne Cycloaddition.
The azide-alkyne cycloaddition provides a powerful tool for bio-orthogonal labeling of proteins, nucleic acids, glycans, and lipids. In some labeling experiments, e.g., in proteomic studies involving affinity purification and mass spectrometry, it is convenient to use cleavable probes that allow release of labeled biomolecules under mild conditions. Five cleavable biotin probes are described for use in labeling of proteins and other biomolecules via azide-alkyne cycloaddition. Subsequent to conjugation with...
Matching Channels
Antibody-drug conjugates are designed to combine the specificity of antibodies directed against tumor-associated targets with potent cytotoxity. Upon internalization of the ADC, the antibody-bound c...
Matching News
Type: Original PaperSodium-dependent multivitamin transporter (SMVT) is a vital transmembrane protein responsible for translocating biotin and other essential cofactors such as pantothenate and lipoat...
Double functionalisation of titanium-based nanoparticles for drug delivery
Scientists in India report the functionalisation of TiO2 nanoparticles with two different biomolecules – tris-(nitrilo tris-acetic acid) and biotin. The biocompatible nanoparticles is non-cytotoxic...
Type: Original PaperThe current study aims to develop a stable pH-sensitive drug delivery system. First, cleavable polyethylene glycol-α-tocopherol hemisuccinate (PEG-THS) was synthesized. Convention...
Background: BioH is one of the key enzymes to produce the precursor pimeloyl-ACP to initiate biotin biosynthesis de novo in bacteria. To date, very few bioH genes have been characterized. In this stud...
Singular phase nano-optics in plasmonic metamaterials for label-free single-molecule detection
A suitably engineered plasmonic metamaterial featuring topologically protected sharp phase variations close to a zero-reflection point of incident lightwaves has now been demonstrated. Exploiting the...
Type: Original PaperPurposeTo study the effects of backbone composition and charge of biotin-functionalized metal-chelating polymers (Bi-MCPs) for 111In complexed to streptavidin (SAv)-trastuzumab Fab...
The NIH announces a novel method for fast, simple, and accurate detection of nucleic acids outside the modern laboratory. Nucleic acid testing is highly specific and often provides definitive identif...
Upsher-Smith Introduces Nexa® Plus Advanced Formula Prescription Prenatal Vitamin
MAPLE GROVE, Minn., Sept. 11, 2012 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. [http://www.upsher-smith.com] today introduced its newest addition to the Nexa® prenatal vitamin famil...
Matching PubMed Articles
Cleavable trifunctional biotin reagents for protein labelling, capture and release.
Trifunctional biotin reagents incorporating cleavable linkers are evaluated for their usage in protein enrichment. A linker based on the Dde protecting group leads to efficient release of protein targ...
Cleavable Biotin Probes for Labeling of Biomolecules via Azide-Alkyne Cycloaddition.
The azide-alkyne cycloaddition provides a powerful tool for bio-orthogonal labeling of proteins, nucleic acids, glycans, and lipids. In some labeling experiments, e.g., in proteomic studies involving...
The interaction between streptavidin and biotin is one of the strongest non-covalent interactions in nature. Streptavidin is a widely used tool and a paradigm for protein-ligand interactions. We recen...
This work was to report preparation and quality control of targeted microbubbles (MB(t)) via biotin-avidin bridge, specifically verification of the "biotin-avidin-biotin" sandwich structure. (1) Lipid...
The valency of quantum dot nanoparticles conjugated with biomolecules is closely related to their performance in cell tagging, tracking, and imaging experiments. Commercially available streptavidin co...
