Search Results for "Cleavage Of Hippocalcin"
Original Source: AP-1 inhibitory peptides attenuate in vitro cortical neuronal cell death induced by kainic acid.
This study has assessed the neuroprotective efficacy of five AP-1 inhibitory peptides in an in vitro excitotoxicity model. The five AP-1 inhibitory peptides and controls of the JNK inhibitor peptide (JNKI-1D-TAT) and TAT cell-penetrating-peptide were administered to primary cortical neuronal cultures prior to kainic acid exposure. All five AP-1 inhibitory peptides and JNKI-1D-TAT provided significant neuroprotection from kainic acid induced neuronal cell death. Kainic acid exposure induced caspase and calpa...
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One of the main pillars of current drug discovery and development activities in the pharmaceutical industry for Alzheimer's disease is prevention of the accumulation of misfolded proteins, i.e....
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Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation
RNA 3′-end formation is thought to be crucial in controlling gene expression. Direct RNA sequencing was used to analyze the 3′ ends of Arabidopsis thaliana RNA in unprecedented detail, revealing e...
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
The 3′ region extraction and deep sequencing (3′READS) method accurately identifies cleavage and polyadenylation sites, avoiding common artifacts and detecting sites in A-rich contexts. It was use...
Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO
Oligomeric Trax–Translin complexes, known as C3PO, are involved in RNA interference and tRNA processing in eukaryotic species including humans. Structural and functional analysis of a Trax-like prot...
[Comment] First-in-human trial of Dz13 for nodular basal-cell carcinoma
Nucleic-acid-based drugs are a novel class of drugs with great therapeutic potential. Among these are DNAzymes, which contain short stretches of single-stranded DNA molecules synthesised in vitro. A D...
The catalytic mechanism for aerobic formation of methane by bacteria
Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highl...
News From The Journal Of Clinical Investigation: Dec. 3, 2012
Researchers inhibit plaque formation in a mouse model of Alzheimer's disease Alzheimer's disease is characterized by the accumulation of protein plaques in the brain. The plaques are generated by BAC...
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6
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Although muscarinic acetylcholine receptors (mAChRs) and NMDA receptors (NMDARs) are important for synaptic plasticity, learning and memory, the manner in which they interact is poorly understood. We...
Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5-8.7% of CRCs. It has been shown that SAC has a poorer prognosis and has different molecular an...
Hippocalcin (Hpca) is a Ca(2+)-binding protein that is expressed in neurons and contributes to neuronal plasticity. We purified a 48kDa Hpca-associated protein from rat brain and identified it to be t...
Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis.
Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to be...
Sequence-specific ultrasonic cleavage of DNA.
We investigated the phenomenon of ultrasonic cleavage of DNA by analyzing a large set of cleavage patterns of DNA restriction fragments using polyacrylamide gel electrophoresis. The cleavage intensity...
