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10:10 EDT 30th March 2015 | BioPortfolio

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Uveitis

There are many different types of Uveitis. This is because: * The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when...

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A New Study May Have an Answer to Treating Cocaine Addiction

USA (PRWEB) February 27, 2015 Cocaine is an extreme stimulant, causing the people who take it to experience intense depression and hostility. In a joint effort between Australian and American unive...

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine administration in mouse nucleus accumbens, where it ...

Creating a Treatment for Cocaine Addiction

Unlike other drug addictions, there are no pharmacological treatments for cocaine dependence. According to Arizona State University School of Life Sciences professor Janet Neisewander, it’s beca...

Potential treatment target for cocaine addiction identified by study

A potential target for therapies to treat cocaine addiction has been identified by researchers. In their study, the investigators find evidence that changing one amino acid in a subunit of an importan...

Study IDs Possible Target to Treat Cocaine Addiction

A study led by investigators from Massachusetts General Hospital and the Perelman School of Medicine at the University of Pennsylvania  has identified a potential target for therapies to treat cocain...

Cocaine Study Raises Questions About Addictions

International research involving the University of Adelaide has pointed to a potential new treatment for cocaine addiction, and could have implications for all types of drug addictions, according to t...

Brief Intermittent Cocaine Self-Administration and Abstinence Sensitizes Cocaine Effects on the Dopamine Transporter and Increases Drug Seeking

Dopamine discovery brings cocaine addiction antidote a bit closer

Researchers studying the mechanism behind a protein dopamine transporter say their work could help in the development of future medical treatment against cocaine addiction. According to the European M...

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Powder and Crack Cocaine Use Among Opioid Users: Is All Cocaine the Same?

Problematic cocaine use is highly prevalent and is a significant public health concern. However, few investigations have distinguished between the 2 formulations of cocaine (ie, powder and crack cocai...

A randomized, double-blind, placebo-controlled trial of RBP-8000 in cocaine abusers: Pharmacokinetic profile of RBP-8000 and cocaine and effects of RBP-8000 on cocaine-induced physiological effects.

Abstract RBP-8000 is a double mutant cocaine esterase that rapidly metabolizes cocaine. This study was conducted to assess the pharmacokinetics of cocaine and cocaine-induced physiological effects in ...

Multiple gastrointestinal complications of crack cocaine abuse.

Cocaine and its alkaloid free base "crack-cocaine" have long since been substances of abuse. Drug abuse of cocaine via oral, inhalation, intravenous, and intranasal intake has famously been associated...

A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.

A long-acting, thermostable bacterial cocaine esterase (CocE) has been identified that rapidly degrades cocaine with a KM of 1.33+0.085 μM. In vivo evaluation of CocE has shown protection against c...

Radiographic features of intracorporeally smuggled liquid cocaine.

The radiological features of intracorporeally smuggled cocaine powder are well-established. Liquid cocaine is a novel method for intracorporeal drug smuggling. We describe radiological features of liq...

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