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11:01 EDT 25th August 2016 | BioPortfolio

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Uveitis

There are many different types of Uveitis. This is because: * The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when...

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Why is cocaine so addictive? Study using animal model provides clues

Scientists are one step closer to understanding what causes cocaine to be so addictive. Using an animal model, researchers have discovered that cocaine leaves a long-lasting imprint on the dopamine sy...

Embera wins $11M NIDA grant for cocaine addiction treatment EMB-001

Embera NeuroTherapeutics, a specialty pharmaceutical company developing novel treatments for cocaine, nicotine, and other addictions, has received an $11.1 million, three-year grant from the National ...

Psychostimulant Promising for Long-term Cocaine Dependence

Sustained-release dexamfetamine reduces cocaine use in patients with long-term cocaine dependence who are receiving heroin-assisted treatment, but is it the 'holy grail'? Medscape Medical News

Researchers study how fluctuating hormones affect female vulnerability to cocaine addiction

Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to c...

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Cocaine and morphine produce similar addiction-related behaviors, but different adaptations at accumbens synapses. The authors explain this paradox, showing that both drugs generate silent synapses in...

Cocaine vaccine gets approved for clinical trial on humans

Addicted to cocaine? There might be some hope if you’re longing to kick the addictive drug.

Molecule in brain may drive cocaine addiction, scientists show

Increased levels of a molecule in the brain, called hypocretin, may contribute to cocaine addiction, a new study suggests. The research shows that blocking hypocretin may reduce compulsive drug-seekin...

UTA psychologist studies how fluctuating hormones affect female vulnerability to cocaine addiction

(University of Texas at Arlington) Researchers at the University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of coca...

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Location-specific immunodetection of cocaine on banknotes.

A novel in-gel bioanalytical immunodetection method has been developed to determine both the presence and the location of cocaine on the surface of banknotes. The cocaine was 'fixed' to the surface of...

Oxytocin Decreases Cocaine Taking, Cocaine Seeking, and Locomotor Activity in Female Rats.

Oxytocin has been shown to decrease cocaine taking and seeking in male rats, suggesting potential treatment efficacy for drug addiction. In the present study, we extended these findings to the assessm...

Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.

The combined molecular dynamics (MD) and potential of mean force (PMF) simulations have been performed to determine the free energy profile of the CocE)-(+)-cocaine binding process in comparison with ...

Specificity and ligand affinities of the cocaine aptamer; impact of structural features and physiological NaCl.

The cocaine aptamer has been seen as a good candidate for development as a probe for cocaine in many contexts. Here, we demonstrate that the aptamer binds cocaine, norcocaine and cocaethylene with sim...

Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration.

Limited oral fluid (OF) pharmacokinetic data collected with commercially available collection devices after controlled cocaine administration hinder OF result interpretations. Ten cocaine-using adults...

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