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09:35 EDT 1st July 2016 | BioPortfolio

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Uveitis

There are many different types of Uveitis. This is because: * The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when...

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Psychostimulant Promising for Long-term Cocaine Dependence

Sustained-release dexamfetamine reduces cocaine use in patients with long-term cocaine dependence who are receiving heroin-assisted treatment, but is it the 'holy grail'? Medscape Medical News

New approach offered to treating cocaine addiction

An FDA-approved drug used for diabetes and obesity may also reduce cocaine dependence, new research indicates. The drug, trade name Byetta, derives from a naturally occurring hormone called glucagon-l...

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Cocaine and morphine produce similar addiction-related behaviors, but different adaptations at accumbens synapses. The authors explain this paradox, showing that both drugs generate silent synapses in...

Mouse Study Shows Cocaine Ravages Brain Cells

MONDAY, Jan. 18, 2016 -- In mice, high doses of cocaine cause brain cells to eat themselves, researchers report. The Johns Hopkins University scientists also found such destruction in the brain cells ...

Cocaine Induces Neuronal Autophagy

A new study supports the idea that cocaine triggers brain cells to eat themselves and suggests a possible antidote.

Cocaine users present alterations in function, structures of brain

The presence of alterations in brain functioning and structure in cocaine users has been seen in a new study where researchers used three different magnetic resonance imaging techniques to study the b...

Carrots and sticks fail to change behavior in cocaine addiction

People who are addicted to cocaine are particularly prone to developing habits that render their behavior resistant to change, regardless of the potentially devastating consequences, suggests new rese...

Carrots and sticks fail to change behaviour in cocaine addiction

People who are addicted to cocaine are particularly prone to developing habits that render their behaviour resistant to change, regardless of the potentially devastating consequences, suggests new res...

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Oxytocin Decreases Cocaine Taking, Cocaine Seeking, and Locomotor Activity in Female Rats.

Oxytocin has been shown to decrease cocaine taking and seeking in male rats, suggesting potential treatment efficacy for drug addiction. In the present study, we extended these findings to the assessm...

Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.

The combined molecular dynamics (MD) and potential of mean force (PMF) simulations have been performed to determine the free energy profile of the CocE)-(+)-cocaine binding process in comparison with ...

Specificity and ligand affinities of the cocaine aptamer; impact of structural features and physiological NaCl.

The cocaine aptamer has been seen as a good candidate for development as a probe for cocaine in many contexts. Here, we demonstrate that the aptamer binds cocaine, norcocaine and cocaethylene with sim...

Oral fluid cocaine and benzoylecgonine concentrations following controlled intravenous cocaine administration.

Limited oral fluid (OF) pharmacokinetic data collected with commercially available collection devices after controlled cocaine administration hinder OF result interpretations. Ten cocaine-using adults...

Cocaine-induced reward enhancement measured with intracranial self-stimulation in rats bred for low versus high saccharin intake.

Rats selectively bred for high (HiS) or low (LoS) saccharin intake are a well-established model of drug-abuse vulnerability, with HiS rats being more likely to consume sweets and cocaine than LoS rats...

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