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05:24 EDT 23rd October 2014 | BioPortfolio

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Uveitis

There are many different types of Uveitis. This is because: * The Uvea is made up of different parts. So if the iris is affected, the condition and its treatment could be totally different to when...

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Mutated Cocaine Esterase Enzyme can be the Potential Cure for Cocaine Overdoses

A mutated enzyme is now the newest weapon in the battle against cocaine overdoses and addiction. Cocaine esterase is a natural enzyme that breaks cocaine down into its inactive components. However, th...

Computational drug design yields cocaine toxicity treatment

(Medical Xpress)—A researcher at the University of Kentucky College of Pharmacy is working to develop the first-ever FDA-approved treatments for cocaine overdose and cocaine addiction.

Cocaine-Busting, Mutant Enzyme Could Treat Overdoses

In the battle against cocaine overdoses and addiction, say hello to scientists’ little friend: a mutated enzyme with an appetite for coke. Roughly 500,000 people visit the emergency room every year...

Subtle changes may occur in neural circuits due to cocaine addiction

Evidence shows that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links betw...

Phenytoin Toxicity From Cocaine Adulteration

Phenytoin (PHT) is commonly used as a cocaine adulterant, but can lead to toxic effects. In this case, a patient developed PHT toxicity after ingesting adulterated crack cocaine. Western Journal of ...

Brief Intermittent Cocaine Self-Administration and Abstinence Sensitizes Cocaine Effects on the Dopamine Transporter and Increases Drug Seeking

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

Exposure to psychostimulants such as cocaine induces synaptic plasticity within the nucleus accumbens (NAc) and alters behavior. Here the authors find a new role for the acid-sensing channel 1A (ASIC1...

Cocaine exposure reorganizes cell type– and input-specific connectivity in the nucleus accumbens

Repeated cocaine exposure enhances excitatory connections onto medium spiny neurons (MSNs) in the nucleus accumbens (NAc). The authors show that cocaine selectively increases basolateral amygdala inpu...

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Powder and Crack Cocaine Use Among Opioid Users: Is All Cocaine the Same?

Problematic cocaine use is highly prevalent and is a significant public health concern. However, few investigations have distinguished between the 2 formulations of cocaine (ie, powder and crack cocai...

A randomized, double-blind, placebo-controlled trial of RBP-8000 in cocaine abusers: Pharmacokinetic profile of RBP-8000 and cocaine and effects of RBP-8000 on cocaine-induced physiological effects.

Abstract RBP-8000 is a double mutant cocaine esterase that rapidly metabolizes cocaine. This study was conducted to assess the pharmacokinetics of cocaine and cocaine-induced physiological effects in ...

Multiple gastrointestinal complications of crack cocaine abuse.

Cocaine and its alkaloid free base "crack-cocaine" have long since been substances of abuse. Drug abuse of cocaine via oral, inhalation, intravenous, and intranasal intake has famously been associated...

A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.

A long-acting, thermostable bacterial cocaine esterase (CocE) has been identified that rapidly degrades cocaine with a KM of 1.33+0.085 μM. In vivo evaluation of CocE has shown protection against c...

Radiographic features of intracorporeally smuggled liquid cocaine.

The radiological features of intracorporeally smuggled cocaine powder are well-established. Liquid cocaine is a novel method for intracorporeal drug smuggling. We describe radiological features of liq...

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