ATX-MS-1467 for patients with multiple sclerosis (MS)

ATX-MS-1467 is a novel treatment that was developed with the aim of working with the immune system to treat the underlying cause of disease rather than just treating the symptoms or suppressing the...

Interleukin 1 IL 1 Receptor IL 1R

Interleukin-1 (IL-1) beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. Current therapy targetin...

TNF-Kinoid

Therapies targeting TNF have already demonstrated efficacy across a wide range of inflammatory diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondulitis, psoria...

Where Is Generic Colchicine?

Dr. Hulisz explains why generic colchicine is no longer available, plus important study results regarding dosing and adverse effects. Medscape Pharmacists

Colchicine may help with heart disease

NEW YORK (Reuters Health) - Colchicine may be helpful as a second-line therapy against heart disease, according to a new study.

Pharmaceutical Research: An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

Type: Review PaperTubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabil...

Colchicine Reduces Events in Secondary Prevention

Investigators showed colchicine reduced the risk of the primary end point--ACS, out-of-hospital cardiac arrest, or noncardioembolic ischemic stroke--by 67%, which was largely driven by a reduction in...

Colchicine Postablation Reduces Early AF Recurrences

In addition to reducing early atrial-fibrillation recurrence, colchicine significantly reduced CRP and IL-6 levels, suggesting the reduction in recurrences is mediated through the inflammatory respons...

Colchicine cuts risk of early AF recurrence after ablation

NEW YORK (Reuters Health) - The gout drug colchicine can help prevent early recurrence of atrial fibrillation (AF) after pulmonary vein isolation, a new randomized controlled study shows.

Zelboraf dosing rework

NIBR and UCSF researchers have shown that altering the dosing regimen of Zelboraf can prevent the development of drug resistance in mouse models of melanoma. The team will now test an intermittent Zel...

Peristaltic Pumps for the Pharmaceutical Industry

Vederflex have provided an award winning pharmaceutical dosing pump for MethaMeasure, helping to deliver a new kind of methadone dosing system. The pump will automate the dosing process, making rehab...

Effects of colchicine-induced microtubule depolymerization on TRPV4 in rats with chronic compression of the dorsal root ganglion.

The aim of this study was to investigate the effect of colchicine-induced microtubule depolymerization on allodynia in rats with chronic compression of the dorsal root ganglion (DRG) (CCD) and the eff...

Letter by Gomez et al Regarding Article, "Colchicine Reduces Postoperative Atrial Fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) Atrial Fibrillation Substudy".

COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial.

Aims No drug has been proven efficacious to prevent the post-pericardiotomy syndrome (PPS), but colchicine seems safe and effective for the treatment and prevention of pericarditis. The aim of the COl...

Neuroprotection by Nicotine Against Colchicine-Induced Apoptosis is Mediated by PI3-Kinase-Akt Pathways.

ABSTRACT Although nicotine is known to protect against β-amyloid (Aβ)-induced neurotoxicity, the effect of nicotine on colchicine-induced neurotoxicity remains unknown. Colchicine is a microtubule-i...

Colchicine Reduces Postoperative Atrial Fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) Atrial Fibrillation Substudy.

Background- Inflammation and pericarditis may be contributing factors for postoperative atrial fibrillation (POAF), and both are potentially affected by antiinflammatory drugs and colchicine, which ha...