Thrombin-Collagen

Thrombin-Collagen Gel

Thrombin Collagen Plasma

Vitamin C

Vitamin C is a water-soluble vitamin that is necessary to form collagen; so is implicated in the synthesis of skin, scar tissue, tendons, ligaments, and blood vessels, the healing of wounds, and for...

Vitamin C Toxicity

Vitamin C (ascorbic acid) plays a role in collagen, carnitine, hormone, and amino acid formation. It is essential for wound healing and facilitates recovery from burns. Vitamin C is also an antioxid...

Autophagy as a Therapeutic Target in Multiple Diseases

Autophagy is a route for degradation of aggregated cellular proteins and dysfunctional organelles. This eBriefing reviews molecular mechanisms that lead to impaired autophagy and strategies for modula...

New Autophagy Inhibitors Block Cancer Growth in Animal Models

A recent paper described the synthesis and characterization of bisaminoquinoline autophagy inhibitors that potently inhibit autophagy and impair...

Identification of a candidate therapeutic autophagy-inducing peptide

A cell-permeable peptide is constructed that is derived from a region of an essential autophagy protein called beclin 1; the peptide is a potent inducer of autophagy in mammalian cells and in vivo in...

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

Voinnet and colleagues show that autophagy targets RNAi components DICER and AGO2 for degradation when they are not bound to miRNA. The autophagy receptor NDP52 is required for this homeostatic regula...

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures

An early step in the autophagy process is the conjugation of the ubiquitin-like proteins (UBLs) Atg8 and Atg12 to their targets. Structural and functional experiments reveal how the autophagy E1 Atg7...

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

mTOR inhibition induces autophage-mediated degradation but few mTOR targets in the process have been identified so far. Cecconi and colleagues show that mTOR inhibits the autophagy regulator AMBRA1 by...

Dialing down autophagy: Sidebar: MD Pharma AB Corporate Profile

MD Pharma AB: Dialing down autophagy MD Pharma AB Lund, Sweden Technology: Small molecule inhibitors of autophagy Disease focus: Musculoskeletal Clinical status: Discovery Founded: 2011 by Madeleine D...

Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine

The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse themselve...

Molecules and Their Functions in Autophagy.

Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 years, yeast genetic screens led to the identification of a number of genes...

Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation.

Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules...

The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction.

Autophagy is a membrane trafficking process involved in intracellular degradation and recycling in eukaryotic cells. DRAM2 (damage-regulated autophagy modulator 2) is a homologue of DRAM that regulate...

The RB-E2F1 Pathway Regulates Autophagy.

Autophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence suggests that this cellular process is also a tumor suppressor pathway. Previous studies showed...

Intersection of autophagy with pathways of antigen presentation.

Traditionally, macroautophagy (autophagy) is viewed as a pathway of cell survival. Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutri...