Search Results for "Cp450 Substrates"
Original Source: Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans.
Pigs are becoming increasingly used as a test animal both in pharmacological and toxicological assessment of new drug compounds. For interspecies comparisons and predictions it is important to characterize the expression and function of membrane transport and enzymatic proteins in pigs, particularly at a mechanistic level which will make extrapolation of observation between pig and man to be made with more confidence. The major objective of this report was to increase the integrative knowledge of drug metab...
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Enzymes - news, views, reports
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into diff...
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Emerging themes in SecA2-mediated protein export
Most protein export in bacteria occurs through the Sec pathway and relies on the essential ATPase SecA to push substrates through the SecYEG translocon. Here, Braunstein and Feltcher describe how myco...
Vaccine Safety Screening For Adventitious Agents Looms Large At Substrates Cmte.
FDA’s Vaccine and Related Biological Products Advisory Committee will examine the role of emerging technologies for detecting adventitious agents in assessing whether novel human tumor-derived cell-...
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
BACE1 (β-secretase) mediates plasma membrane shedding of the amyloid precursor protein (APP), the first step in the generation of A(β) peptide in Alzheimer’s disease. A novel quantitative secretom...
Solon, Ohio (PRWEB) March 31, 2013 Chemiluminescent substrates are standard reagents for the detection of horseradish peroxidase (HRP) in Western blotting. Not all substrates perform equally, howev...
Trees used to create recyclable, efficient solar cell
Solar cells are just like leaves, capturing the sunlight and turning it into energy. It’s fitting that they can now be made partially from trees. Georgia Institute of Technology and Purdue Universit...
EMBL Chemical Biology: Greasy Labels
Just to emphasize how careful you have to be with all these probes and labels, consider what I'm hearing now from Remigiusz Serwa of the Tate group at Imperial College. His group is looking at farnesy...
The physical state of lipid substrates provides transacylation specificity for tafazzin
CoorsTek Introduces High-Performance Aluminum Nitride Substrates
GOLDEN, Colo., Feb. 12, 2013 (GLOBE NEWSWIRE) -- CoorsTek, the world's largest technical ceramics manufacturer, today announced introduction of aluminum nitride substrates. Ideal for the rapidly grow...
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Transfer-Printing of As-Fabricated Carbon Nanotube Devices onto Various Substrates.
Exact replicas of carbon nanotube devices as fabricated on SiO(2) /Si substrates are prepared on various non-conventional substrates such as nonplanar or soft substrates by a simple, yet versatile, tr...
Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic.
As more microfluidic applications emerge for clinical diagnostics, the choice of substrate and production method must be considered for eventual regulatory approval. In this review, we survey recent d...
NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway.
Ubiquitin and ubiquitin-like proteins use unique E1, E2, and E3 enzymes for conjugation to their substrates. We and others have recently reported that increases in the relative concentration of the ub...
Vertical ZnO nanowire growth on metal substrates.
Vertical growth of ZnO nanowires is usually achieved on lattice-matched substrates such as ZnO or sapphire using various vapor transport techniques. Accomplishing this on silicon substrates requires t...
Structural Contributions of Substrates to their Binding to P-Glycoprotein. A TOPS-MODE Approach.
A topological substructural molecular design approach (TOPS-MODE) has been used to formulate structural rules for binding of substrates of P-glycoprotein (P-gp). We first review some of the models dev...
