Search Results for "Crizotinib Src Kinase"

21:35 EST 29th January 2015 | BioPortfolio

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Polo like kinase Plk 1

Polo-like kinase (Plk) is an important cell cycle regulatory kinase that has been implicated in a multitude of cell cycle events. Plks form a family of four different proteins that regulates many as...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Checkpoint kinase 1 CHK 1

Progression through the cell cycle is monitored by surveillance mechanisms known as cell cycle checkpoints. Dysfunction in cell cycle checkpoints leads to genomic instability and contributes to tumo...

Kinases Raf Inhibitors

The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target because it represents a common downstream pathway for several key growth factor tyrosine kinase receptors which are often mutated or...

Matching News

Crizotinib treatment effective against ROS1-positive lung cancer, study suggests

Treatment with the targeted therapy drug crizotinib effectively halted the growth of lung tumors driven by rearrangements of the ROS1 gene in a small clinical trial.

Crizotinib treatment effective against ROS1-positive lung cancer

(Massachusetts General Hospital) Treatment with the targeted therapy drug crizotinib effectively halted the growth of lung tumors driven by rearrangements of the ROS1 gene in a small clinical trial.

Kinase inhibitors: An allosteric add-on

Development of highly specific kinase inhibitors has been a long-standing challenge in chemical biology. The structural and mechanistic characterization of an Erk1/2 kinase inhibitor provides new stra...

c-jun N-terminal kinase (JNK); MAP kinase 1 (MAPK1; ERK-2); MAP kinase 3 (MAPK3; ERK-1)

Cardiovascular INDICATION: Cardiovascular In vitro and rodent studies suggest ophiopogonin D could help prevent doxorubicin-induced cardiotoxicity.

FDA Grants Breakthrough Therapy Designation to AP26113 for ALK-Positive NSCLC

The U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to an investigational agent AP26113 for patients with anaplastic lymphoma kinase (ALK)-positive metastatic nonâ...

FAK in cancer: mechanistic findings and clinical applications

Focal adhesion kinase (FAK) can promote tumour growth and metastasis through various kinase-dependent and kinase-independent pathways. This Review discusses the roles of FAK in tumour cells and cells ...

Xalkori™ (crizotinib) Targeted Therapy More Effective Than Chemotherapy for Treatment of Lung Cancer

A new drug Xalkori™ (crizotinib) is more beneficial than chemotherapy for certain individuals with lung cancer according to new research published in the New England Journal of Medicine. Lung cance...

Big data study identifies new potential target coating for drug-eluting stents

(Cardiovascular Research Foundation) A new study has identified an FDA approved cancer drug, crizotinib, as a possible new coating for drug-eluting stents. Researchers found that crizotinib in mice he...

Matching PubMed Articles

Successful Crizotinib Rechallenge After Crizotinib-induced Interstitial Lung Disease.

We report the case of a 70-year-old Japanese male diagnosed with advanced lung adenocarcinoma harboring the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene. As ...

Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer.

Crizotinib, a c-MET/ALK inhibitor, has exhibited antitumor efficacy in different types of cancers. However, studies regarding Crizotinib in pancreatic cancer have been limited. Thus, we investigated t...

Ceritinib in ALK-Rearranged Non-Small-Cell Lung Cancer.

To the Editor: Shaw and colleagues (March 27 issue)(1) report that ceritinib can overcome crizotinib resistance in patients with non-small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma ki...

Ceritinib in ALK-Rearranged Non-Small-Cell Lung Cancer.

To the Editor: Shaw and colleagues (March 27 issue)(1) report that ceritinib can overcome crizotinib resistance in patients with non-small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma ki...

P-loop Conformation Governed Crizotinib Resistance in G2032R-Mutated ROS1 Tyrosine Kinase: Clues from Free Energy Landscape.

Tyrosine kinases are regarded as excellent targets for chemical drug therapy of carcinomas. However, under strong purifying selection, drug resistance usually occurs in the cancer cells within a short...

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