Systemic lupus erythematosus

Lupus is a systemic autoimmune disease that can affect any part of the body. As with other autoimmune diseases, the immune system attacks the body’s cells and tissue resulting in inflammation...

Vasculitis

Vasculitis (plural: vasculitides) refers to a heterogeneous group of disorders that are characterized by inflammatory destruction of blood vessels. Vasculitis is primarily due to leukocyte migration...

Systemic Lupus Erythematosus SLE

Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. Because the antibodies and accompanying cells of inflammation can affect tissues anywhe...

Fludarabine can't replace cyclophosphamide with busulfan myeloablative conditioning

NEW YORK (Reuters Health) - In patients with leukemia and myelodysplastic syndrome who need myeloablative conditioning before allogeneic hematopoietic cell transplantation (HCT), the less toxic...

Treanda Plus Rituxan is Not Inferior to R-CHOP and R-CVP for advanced NHL

The combination of Treanda® (bendamustine) and Rituxan® (rituximab) was found to be noninferior to the commonly used chemotherapy regimens R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincr...

Dendreon: New Provenge Trial Involves Drugs Shown To Shrink Tumors

By Theodore Cohen:Georgia Health Sciences University (GHSU), in collaboration with Dendreon Corporation (DNDN), recently initiated a new Phase 2 study under the direction of Principal Investigator Sam...

Should mycophenolate mofetil replace cyclophosphamide as first-line therapy for severe lupus nephritis?

Cyclophosphamide Promotes Chronic Inflammation–Dependent Immunosuppression and Prevents Antitumor Response in Melanoma

Study: chemotherapy shortages negatively affecting cancer patients

Researchers at St. Jude Children's Research Hospital and colleagues reported data from a retrospective analysis of Hodgkin's lymphoma patients indicating that chemotherapy shortages over the past thre...

[Comment] Therapy for diffuse large B-cell lymphoma: getting personal

In 1979, Jones and colleagues showed that CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) was superior to CVP (cyclophosphamide, vincristine, and prednisone) in treatment of patients...

Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model

Feasibility of prior administration of cyclophosphamide in TC combination treatment.

BACKGROUND: TC (docetaxel 75 mg/m(2) and cyclophosphamide 600 mg/m(2) q3w) combination is used for neoadjuvant/adjuvant chemotherapy in primary breast cancer. The incidence of allergic reaction is...

Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case-control study.

Sterile haemorrhagic cystitis (SHC) is a known risk of cyclophosphamide treatment; however, most canine reports are case series. This case-control study examined risk factors for SHC in dogs with lymp...

Cyclophosphamide-induced generalised reticulated skin pigmentation: a rare presentation.

Case We describe a 55-year-old woman suffering from Sezary syndrome, had undergone chemotherapy consisting of cycles of cyclophosphamide and prednisone. 10 months later, she noticed a progressively in...

A comparison of lenalidomide/dexamethasone versus cyclophosphamide/lenalidomide/dexamethasone versus cyclophosphamide/bortezomib/dexamethasone in newly diagnosed multiple myeloma.

Novel agents are considered standard components of induction therapy for newly diagnosed patients with multiple myeloma. We retrospectively compared the results of three consecutive phase 2 clinical t...

Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells.

The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine...