Search Results for "Dabigatran Creatinine Clearance Clinical Trials"
Original Source: Dabigatran in atrial fibrillation: pharmacology and clinical trials.
The central pharmacologic approach to stroke prevention in atrial fibrillation has recently changed with the approval of dabigatran by the US Food and Drug Administration (FDA). Dabigatran is an oral anticoagulant that belongs to the class of direct thrombin inhibitors. Dabigatran has predictable pharmacokinetics, without significant drug and food interactions, rapid onset, and requires twice-daily administration without the need for monitoring. The only drug contraindicated with dabigatran is rifampin. In...
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2 new papers on dabigatran etexilate (Pradaxa) and intracranial hemorrhage
(Journal of Neurosurgery Publishing Group) The Journal of Neurosurgery Publishing Group is pleased to announce publication of two new studies on dabigatran etexilate (Pradaxa) and intracranial hemorrh...
Dabigatran decreases risk of recurrent venous thromboembolism
New findings from two double-blind, randomized trials, RE-MEDY and RE-SONATE, show that dabigatran 150 mg twice daily reduces the risk of recurrent venous thromboembolism (VTE).
Diagnosis and treatment of lupus nephritis flares—an update
Flares of systemic lupus erythematosus are broadly defined as an increase in disease activity requiring an intensification of therapy. A renal flare is indicated by an increase in proteinuria and/or s...
Dabigatran etexilate found superior to warfarin in study
RE-LY trial has demonstrated that both doses of dabigatran etexilate (150mg bid and 110 mg bid) offer clinical benefits over warfarin when used in stroke prevention in patients with atrial fibrillatio...
Prosthetic heart valves increase dabigatran risks
Patients with prosthetic heart valves should not be treated with dabigatran because there is an increased risk of thrombosis and bleeding events, the Medicines and Healthcare products Regulatory Agen...
Dabigatran(Pradaxa) in AF: Denmark Experience
And there was no evidence of extra possible risks from dabigatran that had been suggested by some reports. Heartwire
Acute kidney injury: Creatinine and AKI—through a glass, darkly
Pickering et al. report that unchanging plasma creatinine levels after resuscitated cardiac arrest can indicate substantial acute kidney injury (AKI) as confirmed by increased levels of AKI biomarker...
Dabigatran exposure may RE-LY on genetics
Researchers have found that variants in the ABCB1 and CES1 genes are associated with increased dabigatran plasma levels in patients taking the oral anticoagulant.
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BACKGROUND: Plasma concentrations of the anticoagulant dabigatran are correlated with clinical outcomes, and are affected by renal function, intestinal P-glycoprotein (P-gp) activity and stomach acidi...
Dabigatran in atrial fibrillation: pharmacology and clinical trials.
The central pharmacologic approach to stroke prevention in atrial fibrillation has recently changed with the approval of dabigatran by the US Food and Drug Administration (FDA). Dabigatran is an oral...
Whether drug-eluting stents are effective and safe in patients with moderate renal insufficiency (RI) is unknown. We performed a pooled analysis of data from 3 blinded randomized trials of sirolimus-e...
PURPOSE: Prospective, double-blind studies in orthopaedic patients have been conducted using the direct thrombin inhibitor dabigatran etexilate (hereafter referred to as dabigatr...
Objective-To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. Animals-6 young adult cats. Procedures-3 sexuall...
