Generalized dystonia dystonia musculorum deformans

Renal Replacement Therapy

Eliglustat

Eliglustat acts at a level above the defective enzyme in Gaucher disease and reduces the amount of a toxic metabolite (glucosylceramide) that is the target of enzyme replacement therapy.

Psoriasis

Psoriasis is a common skin condition affecting 2-3% of the population of the United Kingdom, where the skins replacement process is sped taking 2-6 days instead of the usual 21 - 28 days for the rep...

Gaucher's disease

Gaucher's (go-SHAYZ) disease occurs when certain harmful fatty substances accumulate to excessive levels in your liver, spleen, lungs, bone marrow and, less commonly, brain. This accumulation of...

DBS Benefits in Dystonia May Linger After Device Shut-Off

New report adds to a 'small but emerging' body of evidence of lingering motor benefit in dystonia after interruption of neurostimulation. Medscape Medical News

[Articles] Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial

3 years and 5 years after surgery, pallidal neurostimulation continues to be an effective and relatively safe treatment option for patients with severe idiopathic dystonia. This long-term observation...

Concurrent Botox Treatment of Cervical Dystonia and Migraine

Chronic headache, including migraine, may commonly occur with cervical dystonia. Can onabotulinumtoxinA effectively treat both disorders concurrently? Headache

Psychogenic Dystonia Differs From Organic Disease

A new brain imaging study compared psychogenic and organic dystonia, with findings that may open new avenues for treatment of psychogenic disorders. Medscape Medical News

Botulinum toxin helpful in cervical dystonia with migraine

NEW YORK (Reuters Health) - In patients with cervical dystonia and concurrent migraine, onabotulinum toxin A (Botox, Allergan) is effective in controlling symptoms, Florida-based researchers repor...

First dystonia gene found in African-Americans

A pair of studies tells the tale of how a neuroscientist at Mayo Clinic in Florida helped to discover the first African-American family to have inherited the rare movement disorder dystonia, which cau...

Discovery of Genetic Basis for Dystonia Brings Opportunity for Development of Diagnostic Tests, Novel Treatments

Scientists from Beth Israel Medical Center and the Icahn School of Medicine at Mount Sinai have announced the discovery of a novel gene for primary torsion dystonia, a debilitating neurological disord...

Study now tells physicians that dystonia can occur in African-American patients

A pair of studies tells the tale of how a neuroscientist at Mayo Clinic in Florida helped to discover the first African-American family to have inherited the rare movement disorder dystonia, which cau...

Less Is More: Adaptation of Voltage after Battery Replacement in Deep Brain Stimulation for Dystonia.

Background: To maintain the efficacy of deep brain stimulation (DBS) on dystonic symptoms, slight incremental increase in voltage may be necessary over years after a steady state has been reached foll...

Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor.

ABSTRACT: BACKGROUND: There is an ongoing debate whether essential tremor (ET) represents a monosymptomatic disorder or other neurologic symptoms are compatible with the diagnosis of ET. Many patients...

Neurophysiology of dystonia: The role of inhibition.

The pathophysiology of dystonia has been best studied in patients with focal hand dystonia. A loss of inhibitory function has been demonstrated at spinal, brainstem and cortical levels. Many cortical...

Which patients with dystonia benefit from deep brain stimulation? A metaregression of individual patient outcomes.

There is substantial variability in the responsiveness of dystonia patients to deep brain stimulation (DBS), presumably due to the multiple causes of dystonia. This article presents the results of an...

Impact of increasing current drain in a pacemaker operating during activation of the elective replacement indicator.

The occurrence of a 13.8 s episode of ventricular asystole in a patient whose VVIR pacemaker displayed the elective replacement indicator (ERI) is reported. Increasing battery current drain by VARIO...