Dealkylation Pages on BioPortfolio:

Oxidative dealkylation of drugs and steroid hydroxylation as ...
Oxidative dealkylation of drugs and steroid hydroxylation as catalyzed by rat liver microsomal preparations: A dissertation in pharmacology, , Books, ...
http://www.bioportfolio.com/bookshop/Operation/ItemSearch/Se...

BioPortfolio - Dealkylation
Dealkylation - BioPortfolio - Indepth. ... N-Dealkylation of aliphatic amines and selective synthesis of monoalkylated aryl amines. ...
http://www.bioportfolio.com/indepth/Dealkylation.html...

BioPortfolio - Dealkylation patents
«Dealkylation. Below is an extended Dealkylation patents listing. Click here to return to the Dealkylation main in depth entry. ...
http://www.bioportfolio.com/indepth/Dealkylation/patents.htm...

BioPortfolio - Hydroxylation
Oxidative dealkylation of drugs and steroid hydroxylation as ... Oxidative dealkylation of drugs and steroid hydroxylation as catalyzed by rat liver ...
http://www.bioportfolio.com/search/Hydroxylation.html...

Steroid 11-Beta-Hydroxylase - -
Oxidative dealkylation of drugs and steroid hydroxylation as . ... 21- Hydroxylation Deficiency; 11-Beta Hydroxylase Deficiency . ...
http://www.bioportfolio.com/bookshop/search/Steroid+11-Beta-...

Cytochrome P-450 Cyp1a1 - -
Probe Substrates: -CYP1A1 -7-Ethoxyresorufin O-dealkylation -CYP1A2 -7- Ethoxyresorufin ... http://www.bioportfolio.co.uk/cgi-bin/dialogserver.exe?DB=se
. ...
http://www.bioportfolio.com/bookshop/Operation/ItemSearch/Se...

BioPortfolio - cyp2c19 ppt liver cytochrome
N,O,S – Dealkylation .... Disease – liver disease such a cirrhosis and steatosis ... http://www.tiehh.ttu.edu/mhooper/Docs/Phase-I-Metabolism-I.p.. ...
http://www.bioportfolio.com/search/cyp2c19_ppt_liver_cytochr...

BioPortfolio - Subcellular Fractions patents
7232663, Assays employing novel substrates for measuring P450-mediated N- dealkylation. 7199220, 103P2D6: tissue specific protein highly expressed in
various ...
http://www.bioportfolio.com/indepth/Subcellular_Fractions/pa...

BioPortfolio - CYP2C8 patents
7232663, Assays employing novel substrates for measuring P450-mediated N- dealkylation. 7265143, C-4 substituted retinoids ...
http://www.bioportfolio.com/gene/1558-CYP2C8/patents.html...

Results from other life science and pharmaceutical sites:

Partitioning between N-dealkylation and N-oxygenat...[J Biol Chem ...
P450s can form some N-oxides and hydroxylamines but these are not favored whenever N-dealkylation is possible. However, if a paradigm involving 1-electron
...
http://www.ncbi.nlm.nih.gov/pubmed/8486725...

Microbial models of mammalian metabolism: O-dealkylation of para ...
With Triton X-100 as a solubilizing agent, the relative rates and extent of O- dealkylation of the 4-alkoxybiphenyls, were studied with A. flavus. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=24...

Dealkylation of Phenolic Ethers : Abstract : Nature
SEVERAL methods have been reported in the literature for the dealkylation of ethers; for example, with hydrobromic acid1, hydriodic acid2, ...
http://www.nature.com/nature/journal/v153/n3882/abs/153377a0...

The oxidative dealkylation of insecticidal phosphoric acid ...
The dealkylation of the insecticidal phosphoric acid triester, 2-chloro-1-(2,4- dichlorophenyl)vinyl diethyl phosphate, proceeds in mammalian liver slices ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=11...

Dealkylation of N-Alkylamines by Model Systems
Dealkylation of N-Alkylamines by Model Systems. JAMES R. GILLETTE, JAMES V. DINGELL & BERNARD B. BRODIE. Laboratory of Chemical Pharmacology, National Heart
...
http://www.nature.com/nature/journal/v181/n4613/abs/181898b0...

Variable contribution of CYP2D6 to the N-Dealkylation of S ...
Recombinant cDNA expression systems for CYP2D6 have been shown to have significant catalytic activity with respect to the N-dealkylation of propranolol
. ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20...

Radical cation intermediates in N-dealkylation rea...[Xenobiotica ...
The simplest paradigm has N-oxygenation and N-dealkylation both proceeding ... Evidence for specific base catalysis in N-dealkylation reactions catalyzed by
...
http://www.ncbi.nlm.nih.gov/pubmed/7483667...

Mechanism of dealkylation of clionasterol in the insect Tenebrio ...
Location of this 3H label in the desmosterol showed that dealkylation of the clionasterol involved 3H migration from C-25 to C-24. A possible mechanism for
...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=11...

CYP3A is responsible for N-dealkylation of haloper...[Life Sci ...
CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes. ...
http://www.ncbi.nlm.nih.gov/pubmed/11133003...

Identification of the human cytochrome P450 isoforms mediating in ...
In order to assess the CYP isoforms involved in the N-dealkylation of perphenazine and to ... N-Dealkylation of perphenazine by cDNA-expressed CYP
isoforms ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20...

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