Search Results for "Dectin Polymorphism Hiv"
Original Source: Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans.
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
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Dectin-1 potential target for nasal polyposis
The transmembrane protein Dectin-1 appears to play a role in the pathogenesis of nasal polyposis, providing a potential new target for treating the condition, report Chinese researchers.
Complement components activate and recruit immune cells, promoting host defense and inflammatory disease. Jörg Köhl and his colleagues demonstrate that IgG1 immune complexes inhibit C5a-mediated inf...
CPhI's Polymorphism 2012 annual conference to take place in December
CPhI's annual conference, Polymorphism 2012, is a two-day strategic meet taking place from 19-20 December at Hilton International Airport, Mumbai, India. This event has received a lot of interest from...
Vitamin D receptor polymorphism may protect against osteoporosis
A polymorphism in the vitamin D receptor gene significantly influences risk for osteoporosis, suggest results from a meta-analysis of 26 studies.
Amos Tanay and colleagues characterize DNA methylation polymorphism within cell populations and track immortalized fibroblasts in culture for over 300 generations to show that formation of differentia...
Study suggests adverse role for BclI polymorphism in obesity and insulin resistance
A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The r...
Single Nucleotide Polymorphism Detection by DNA Melting Analysis
A Single Nucleotide Polymorphism (SNP) is defined as a single base pair difference occurring between members of the same species, or between paired chromosomes in an individual. Some SNPs have been a...
An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats
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The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study, the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading to diminished Decti...
The aim of this work was to study the expression and function of the innate immune receptor dectin-1 in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We studied twent...
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community th...
Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
Pattern recognition receptors for fungi include dectin-1 and mannose receptor, and these mediate phagocytosis, as well as production of cytokines, reactive oxygen species, and the lipid mediator leuko...
In this report, we describe the convergent synthesis of β(1,3) oligosaccharides containing an aminoalkyl group. The branched heptadecasaccharide and linear hexadecasaccharide acted as ligands of dect...
