Pediatrics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions...

Singulair

Singulair, the brand name for montelukast sodium, is produced by Merck & Co., Inc. Its annual sales in 2009 were $3m, ranking it 7th in the world. Singulair acts by blocking leukotrienes, to r...

Abilify

Abilify (Aripiprazole) is an atypical antipsychotic produced by Bristol-Myers Squibb Company, with annual sales of $3m, ranking it 6th in the world for annual sales.  Abilify is prescribed in...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Tumor Necrosis Factor TNF Products

Tumor Necrosis Factor (TNF) and TNF receptor antagonists and agonists used to treat TNF-mediated inflammatory diseases such as rheumatoid arthritis or to treat cancer. TNF blockers are the commerc...

[Articles] Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial

Imatinib mesylate could be used to treat plexiform neurofibromas in patients with NF1. A multi-institutional clinical trial is warranted to confirm these results.

FDA committee to discuss low-dose paroxetine mesylate, Serada

FDA's Advisory Committee for Reproductive Health Drugs will meet on March 4 to discuss an NDA from Noven Pharmaceuticals Inc. for low-dose paroxetine mesylate and an NDA from Depomed Inc. (NASDAQ:DEPO...

FDA Perspective Published in the New England Journal of Medicine Reinforces Safety of Pradaxa (dabigatran etexilate mesylate)

RIDGEFIELD, Conn., March 18, 2013 /PRNewswire/ -- A new perspective from the U.S. Food and Drug Administration (FDA) states the agency has not changed its recommendations regarding Pradaxa®...

Pradaxa (dabigatran etexilate mesylate): Drug Safety Communication - Should Not Be Used in Patients with Mechanical Prosthetic Heart Valves

[Posted 12/19/2012] AUDIENCE: Cardiology, Patients ISSUE: The U.S. Food and Drug Administration (FDA) is informing health care professionals and the public that the blood thinner (anticoagulant) Prada...

The effect of imatinib mesylate on the proliferation, invasive ability, and radiosensitivity of retinoblastoma cell lines

The effect of imatinib mesylate on the proliferation, invasive ability, and radiosensitivity of retinoblastoma cell lines Eye advance online publication, November 16 2012. doi:10.1038/eye.20...

Eisai pharma alliances with DSM for developmental drugs

DSM Pharmaceutical Products announced the signing of a 3 year master supply agreement announcing pharma alliances with Eisai., a big pharma company The agreement covers the production of eribulin mesy...

Amgen, GSK Pediatric Oncology Studies Could Change Based on Advisory Committee Comments

FDA’s pediatric oncology subcommittee will consider the best study designs to isolate pediatric clinical benefit in Amgen’s blinatumomab and whether pediatric use can be extrapolated from adult da...

Recent Literature on Pediatric Antiepileptic Drugs

This article provides an overview of pediatric AED research published during 2012. Pediatric Pharmacotherapy

In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines.

This study evaluated the in vitro activity of masitinib mesylate against canine hemangiosarcoma (HSA) cell lines after treatment with increasing concentrations of masitinib mesylate (0.01-100 µM) f...

Deferoxamine restores callus size, mineralization, and mechanical strength in fracture healing after radiotherapy.

: Therapeutic augmentation of fracture-site angiogenesis with deferoxamine has proven to increase vascularity, callus size, and mineralization in long-bone fracture models. The authors posit that the...

Synthesis of Coronafacic Acid via TBAF-Assisted Elimination of the Mesylate and Its Conversion to the Isoleucine Conjugate.

An aldol reaction followed by elimination of the derived mesylate was used to construct the side chain that was designed to afford the cyclohexene ring of coronafacic acid via intramolecular alkylatio...

Eribulin mesylate.

Eribulin mesylate (Halaven; Eisai) - a synthetic analogue of the marine natural product halichondrin B that interferes with microtubule dynamics - was approved in November 2010 by the US Food and Drug...

Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole.

Purpose To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, on the plasma pharmacokinetics of eribulin mesylate administered by single-dose intravenous i...