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MSD Changes Drug Name Of Arogylcem To Prevent Wrong Prescription

MSD announced July 23 it has changed the name of its hyperinsulinemic hypoglycemia Arogylcem 25mg capsules (diazoxide) to “MSD” Diazoxide 25mg capsules.

AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury....

Diazoxide maintenance of myocyte volume and contractility during stress: Evidence for a non-sarcolemmal K(ATP) channel location.

OBJECTIVE: Animal and human myocytes demonstrate significant swelling and reduced contractility during exposure to stress (metabolic inhibition, hyposmotic stress, or hyperkalemic cardioplegia), and t...

Diazoxide inhibits aortic endothelial cell apoptosis in diabetic rats via activation of ERK.

Endothelial cell (EC) survival is critical in the maintenance of endothelial function as well as in the regulation of angiogenesis and vessel integrity since endothelial dysfunction is the initial les...

Diazoxide attenuates indomethacin-induced small intestinal damage in the rat.

ATP-sensitive potassium (K(ATP)) channel openers have been shown to protect against cellular damage in neurons, cardiac muscle, and kidney and to effectively reduce nonsteroidal anti-inflammatory drug...

Roles of phospho-GSK-3beta in myocardial protection afforded by activation of the mitochondrial K(ATP) channel.

The aim of this study was to determine roles of glycogen synthase kinase-3beta (GSK-3beta) in cardioprotection by activation of the mitochondrial ATP-sensitive K(+) channel (mK(ATP) channel). In isola...