Antibody classes

An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a...

Substrate-specific structural rearrangements of human Dicer

Human Dicer can process long double-stranded RNA and hairpin precursor RNA to yield short interfering RNAs or microRNAs, respectively. EM and single-particle analyses of Dicer–substrate complexes no...

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

Voinnet and colleagues show that autophagy targets RNAi components DICER and AGO2 for degradation when they are not bound to miRNA. The autophagy receptor NDP52 is required for this homeostatic regula...

Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation

Marine and colleagues use mouse models to show that loss of Dicer or its downstream microRNA cluster miR-17–92 in retinal progenitors prevents retinoblastoma formation through a synthetic lethal int...

Site-specific DICER and DROSHA RNA products control the DNA-damage response

Non-coding RNAs (ncRNAs) are involved in an increasingly recognized number of cellular events. Some ncRNAs are processed by DICER and DROSHA RNases to give rise to small double-stranded RNAs involved...

Dicerna Announces Allowance of Patent Claims Covering Extended Dicer Substrate Therapeutic Structures

Dicerna Pharmaceuticals, Inc., a RNA interference (RNAi) company focused on developing breakthrough oncology therapeutics, announced today that the United States Patent and...

DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem cell proliferation

The biological importance of large numbers of retrotransposon-derived Alu repeats present in the human genome has been mysterious. New research reveals that many Alu repeats are bound and induced by r...

Small RNAs: miRNA machinery disposal

Autophagy regulates microRNAs by degrading DICER and AGO.

Dicerna Announces First Patent Grant in Japan to Dicer Substrate siRNA Molecules

Dicerna Pharmaceuticals, Inc. (Dicerna), a RNA interference (RNAi) company focused on developing breakthrough oncology therapeutics utilizing its proprietary Dicer Substrat...

Canonical and alternate functions of the microRNA biogenesis machinery.

The canonical microRNA (miRNA) biogenesis pathway requires two RNaseIII enzymes: Drosha and Dicer. To understand their functions in mammals in vivo, we engineered mice with germline or tissue-specific...

Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease.

Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for t...

Reduced expression of nuclear Dicer correlates with melanoma progression.

In this study, we found that nuclear expression of Dicer protein is markedly reduced during melanoma progression and positive nuclear Dicer staining correlated with better survival of melanoma patient...

Advance on Dicer gene and its role in female reproduction.

Dicer is an RNAse III endonuclease that is essential for the biogenesis of microRNAs and small interfering RNAs. These small RNAs transcriptionally and post-transcriptionally regulate mRNA expression...

Dysregulated Expression of Dicer and Drosha in Breast Cancer.

Large-scale profiling approaches have revealed global down-regulation of microRNAs (miRNAs) in several human cancer types including breast cancer. Altered expression of Dicer and Drosha, two key enzym...