Search Results for "Disease Gene Repressor"
Original Source: Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.
The expression of the gene products in many methicillin-resistant Staphylococcus aureus (MRSA) strains is regulated by the gene repressor BlaI. Here we show that BlaI is a mixture of monomer and dimer at in vivo concentrations, binds to the operator regions preferentially as a monomeric protein, and the measured dissociation constants and in vivo concentrations account for the basal level transcription of the resistance genes. These observations for the first time provide a quantitative picture of the proce...
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Huntington's disease is a hereditary disease caused by a defect in a single gene on Chromosome 4 that is inherited in an autosomal dominant fashion. The defect causes a part of DNA, called a CAG...
Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synth...
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A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization
A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalizationArabidopsis flowering requires a cold spell (vernalization) involving downregulation of the FLC flowing...
Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the activators, keeps DNA open to enzymes that transcribe DNA into RNA. Their repressor opponents antagonize...
A Transcriptional Co-Repressor Protein Links Obesity to Breast Cancer Risk
Weight gain and high-carbohydrate diets increase risk of developing breast cancer due to the activity of the transcriptional co-repressor...
Carl Zimmer with a wonderful tribute to Francois Jacob:...Strangest of all the mutants Jacob and Monod discovered were ones that produced beta-galactosidase and permease all the time, regardless of wh...
A recent paper published in Blood indicates that the interaction between AML1–ETO and the transcriptional co-repressor NCOR1 is partly responsible for limiting the leukaemogenic capacity of this fus...
Controlling gene expression: How chromatin remodelers block a histone pass
(Stowers Institute for Medical Research) Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the activators, keeps DNA open to enzymes that transcribe DNA into...
Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
Harry Dietz and colleagues report the identification of mutations in SKI in Shprintzen-Goldberg syndrome, which shares features with Marfan syndrome and Loeys-Dietz syndrome. SKI encodes a known repre...
Molecular biology: Protein crawls on chromosome
Proteins that control gene expression by attaching to specific DNA sequences amble along chromosomes until they hit their targets, according to a single-molecule imaging study.In the 1970s, researcher...
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The repressor of sulfur-oxidizing (sox) operon regulates expression of genes encoding a multienzyme complex that governs the chemolithotrophic sulfur oxidation in Pseudaminobacter salycylatoxidans KCT...
The P elements of Drosophila melanogaster are well-studied transposons with both mobilizing and repressor functions. P elements can also variably silence the expression of certain other transgenes thr...
Identification of nuclear factor-κB sites in the Slc2a4 gene promoter.
Glucose transporter GLUT4 protein, codified by Slc2a4 gene plays a key role in glycemic homeostasis. Insulin resistance, as in obesity, has been associated to inflammatory state, in which decreased GL...
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.
The expression of the gene products in many methicillin-resistant Staphylococcus aureus (MRSA) strains is regulated by the gene repressor BlaI. Here we show that BlaI is a mixture of monomer and dimer...
KEY MESSAGE : Peach ERF3b is a potent transcriptional repressor for defense-related genes even in the presence of similar levels of transcriptional activators and can interfere with plant development...
