Search Results for "Doxorubicin Mda Mb 231 Cell Viability"
Original Source: Overexpression of ERp29 attenuates doxorubicin-induced cell apoptosis through upregulation of Hsp27 in breast cancer cells.
The endoplasmic reticulum protein 29 (ERp29) has a critical role in regulating protein folding, maturation and secretion. However, its role in carcinogenesis remains elusive. Recently, we reported that ERp29 is a novel tumor suppressor and regulates mesenchymal-epithelial transition in MDA-MB-231 breast cancer cells. Here, we investigated whether ERp29 plays a role in the response of breast cancer cells to chemotherapeutic agents. We found that expression of ERp29 increased the resistance to doxorubicin, bu...
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Early Embryo Viability Assessment Test (Eeva)
Auxogyn’s non-invasive Early Embryo Viability Assessment Test (Eeva) may improve in vitro fertilization (IVF) outcomes by providing IVF clinics and patients with objective information on embry...
Squamous cell carcinoma (SCC) is a carcinomatous cancer occurring in many different organs, including the skin, lips, mouth, esophagus, urinary bladder, prostate, lungs, vagina, and cervix. It is a...
Stem cells can be found in all multicellular organisms and are characterized by the ability to renew themselves through mitotic cell division and differentiate into a diverse range of specialized ce...
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Identification of the molecular basis of doxorubicin-induced cardiotoxicity
Doxorubicin, which induces tumor cell death through effects on topoisomerase-II, is a commonly used chemotherapeutic agent but has the substantial drawback of causing cardiotoxicity. Edward T.H.Yeh an...
Modified Citrus Pectin Boosts Effectiveness of Doxorubicin Against Prostate Cancer
SANTA ROSA, Calif., July 18, 2012 /PRNewswire/ -- Doxorubicin (Dox) is an effective anti-cancer drug, but it's also a very toxic one, causing severe heart and immune damage. The doses needed to impact...
The monitoring of cell survival and functionality following their in vivo transplantation remains a challenge in clinical cell therapy. Now, using magnetic resonance imaging techniques and microcapsu...
Normal p53 gene makes breast cancer chemotherapy with doxorubicin less effective
Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was...
Type: Original PaperThe purpose of this study was to examine doxorubicin adsorption in polypropylene containers as a function of pH and drug concentration based on anecdotal evidence of such adsorptio...
Type: Original PaperPurposeTo demonstrate the feasibility of a novel macromolecular delivery system for doxorubicin (DOX) which combines pH dependent DOX release with a high molecular weight and biode...
[Comment] Role of the investigator in phase 1 trials of anticancer drugs
For two decades, liposome formulations of many cytotoxic drugs (eg, cisplatin, vinca alkaloids, taxanes, and camptothecin) have been investigated to improve the activity-to-safety ratio. Many clinical...
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This study evaluate the effect of PectaSol on modification of Doxorubicin(Dox) cytotoxicity and apoptosis and cell cycle in prostate cancer cell lines (DU-145 & LNCaP). Combination of PectaSol and Dox...
The objective of this study was to increase the potency of doxorubicin against adriamycin-resistant NCI/ADR-RES cells by concurrent treatment with doxorubicin and MBO-asGCS loaded solid-lipid nanopart...
Doxorubicin-induced cell death requires cathepsin B in HeLa cells.
The cysteine protease cathepsin B acts as a key player in apoptosis. Cathepsin B mediated cell death is induced by various stimuli such as ischemia, bile acids or TNFalpha. Whether cathepsin B can be...
The endoplasmic reticulum protein 29 (ERp29) has a critical role in regulating protein folding, maturation and secretion. However, its role in carcinogenesis remains elusive. Recently, we reported tha...
Down-regulation of ICBP90 contributes to doxorubicin resistance.
Acquired resistance to doxorubicin has become a serious obstacle in breast cancer treatment. The underlying mechanism responsible for this has not been completely elucidated. In this study, a doxorubi...
