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Duchesnay wins US FDA OK for morning sickness drug Diclegis

Duchesnay won the US FDA's approval to market Diclegis (doxylamine succinate 10mg, pyridoxine hydrochloride 10mg) delayed-release tablets as a therapy for nausea and vomiting related to pregnancy in...

Duchesnay introduces Diclegis in US market

Duchesnay USA has announced the availability of Diclegis, a composition of 10mg doxylamine succinate and 10mg pyridoxine hydrochloride (vitamin B6), in US pharmacies.

Diclegis gets FDA approval for treatment of nausea and vomiting of pregnancy

The U.S. Food and Drug Administration today approved Diclegis (doxylamine succinate and pyridoxine hydrochloride) to treat pregnant women experiencing nausea and vomiting.

FDA approves Diclegis for pregnant women experiencing nausea and vomiting

The U.S. Food and Drug Administration today approved Diclegis (doxylamine succinate and pyridoxine hydrochloride) to treat pregnant women experiencing nausea and vomiting.

Morning Sickness Drug "Diclegis" Approved By The FDA

Diclegis (doxylamine succinate and pyridoxine hydrochloride) has just been approved by the U.S. Food and Drug Administration (FDA) for the treatment of nausea and vomiting, commonly known as "morning...

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis wi...

Diclegis doxylamine/pyridoxine regulatory update

FDA approves Duchesnay's morning sickness drug

FDA approved Diclegis doxylamine/pyridoxine from Duchesnay Inc. (Blainville, Quebec) to treat nausea and vomiting of pregnancy in women who do not respond to conservative management, including dietary...

Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: Application to a pharmacokinetic study.

In the present study, a fast, sensitive and robust method to quantify dextromethorphan, dextrorphan and doxylamine in human plasma using deuterated internal standards (IS) is described. The analytes a...

Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.

OBJECTIVE:: To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of preg...

Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy.

Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described. The objective of this study was t...

Identification of the membrane protein SucE and its role in succinate transport in Corynebacterium glutamicum.

Succinic acid is excreted during anaerobiosis by many bacteria, and manifold applications are known making the biotechnological production of succinate attractive. Although the pathways for succinate...

Structure-Directing and Template Roles of Aromatic Molecules in the Self-Assembly Formation Process of 3D Holmium-Succinate MOFs.

Two new holmium-succinate frameworks have been synthesized by hydrolysis in situ of the succinylsalicylic acid under different hydrothermal conditions. Compound 1, [Ho(2)(C(4)H(4)O(4))(3)(H(2)O)(2)]·...