Effect of Suicide

Phyllodes Tumor

Tumor Immunodiagnosis

Local tumor

Tumor recurrence

Local chemotherapy has a stronger effect on reducing tumor growth

Reducing the growth of a tumor by localized delivery of cancer medication can be achieved by using a combination of ultrasound, temperature-sensitive nanoparticles and MRI. This is shown by Mariska de...

Local chemotherapy has a stronger effect on reducing tumor growth, research suggests

Reducing the growth of a tumor by localized delivery of cancer medication can be achieved by using a combination of ultrasound, temperature-sensitive nanoparticles and MRI, new research suggests.

Pharmaceutical Research: Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction Between Erlotinib and Gemcitabine

Type: Original PaperPurposeTo investigate the pharmacological effects of different erlotinib (ER) and gemcitabine (GM) combination schedules by in vitro and in vivo experiments and PK/PD models in non...

Researchers discover novel mechanism of tumor hypoxia

An article published recently in Tumor Microenvironment and Therapy - an open access journal by Versita, defines a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxy...

Combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect: Study

Researchers have discovered that combining chemotherapy drugs and immunotherapy cancer vaccines results in an enhanced anti-tumor effect. The results, achieved by testing cancer cells in a laboratory,...

Attenuation of treatment effect due to measurement variability in assessment of progression‐free survival

For normally distributed data analyzed with linear models, it is well known that measurement error on an independent variable leads to attenuation of the effect of the independent variable on the depe...

A little tag with a large effect: How the epigenetic marker 5-hydroxymethylcytosine is interpreted by neural cells

Scientists report that the marker 5hmC has an effect on gene expression opposite to that of 5mC. Since changes in the distribution of 5hmC are known to take place in a broad range of tumor cells, thes...

Understanding The Causes Of Hypoxia Can Aid In Cancer Detection And Intervention

An article published recently in Tumor Microenvironment and Therapy - an open access journal by Versita, defines a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxy...

The inhibition of the T-cell immunoglobulin and mucin domain 3 (Tim3) pathway enhances the efficacy of tumor vaccine.

T-cell immunoglobulin and mucin domain 3 (Tim3) plays an important role in the Th1-mediated immune response; however, its effect on the efficacy of tumor vaccines has not been fully evaluated. Here, w...

Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.

The objective of this study was to analyze the influence of obesity and insulin resistance on tumor development and, in turn, the effect of insulin sensitizing agents.

Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth.

Despite strong evidence for the involvement of the stroma in Hedgehog signaling, little is known about the identity of the stromal cells and the signaling mechanisms that mediate the growth promoting...

Extracellular HSPA1A promotes the growth of hepatocarcinoma by augmenting tumor cell proliferation and apoptosis-resistance.

Intracellular HSP70 has been implicated as a cytoprotective protein, whereas the effect of extracellular HSP70 on tumor cells has not been fully understood to date. Here we report that extracellular H...

pH-Controlled Delivery of Nanoparticles into Tumor Cells.

Nanoparticles target tumor cells by pH-controlled means: Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediate...