Search Results for "Erk Phosphorylation Pml"
Original Source: Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover.
The promyelocytic leukemia (PML) protein is a tumor suppressor that has an important role in several cellular processes, including apoptosis, viral infection, DNA damage repair, cell cycle regulation, and senescence. PML is an essential component of sub-nuclear structures called PML nuclear bodies (NBs). Our laboratory has previously demonstrated that the peptidyl-prolyl cis-trans isomerase, Pin1, binds and targets PML for degradation in a phosphorylation-dependent manner. To further elucidate the mechanism...
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PKC (protein kinase C) http://www.bioportfolio.com/channels/serine-threonine-protein-kinase-c-pkc is a kinase enzyme and a protein molecule that can change the format of other proteins through chemi...
MAP kinase kinase MEK Inhibitors
The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death. The MAPK pathway has emerged as the crucial route between membrane-bound Ras...
Novel Mitotic Kinase Inhibitors
Mitosis, a central event in tumor growth, is highly regulated to ensure accurate and equal segregation of genetic materials from parent cells to daughter cells. Main effectors of this process are mi...
Mitosis, a central event in tumor growth, is highly regulated to ensure accurate and equal segregation of genetic materials from parent cells to daughter cells. Main effectors of this process are mi...
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Phosphorylation of residues in the N-terminal tail of histone H3 signals different biological outcomes. High-resolution NMR analyses now reveal a mechanistic hierarchy of H3 phosphorylation events, wh...
Using a knock-in strategy to ablate a Cdk5-targeted serine phosphorylation site on residue 478 of the TrkB receptor, the authors demonstrate the role of this phosphorylation in activity-dependent func...
PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP
PI3K-mediated PKCλ activation promotes GluA1-containing AMPAR phosphorylation and incorporation into postsynaptic site during LTP.
TNF-α suppresses regulatory T (Treg) cell function, however the mechanism remains unclear. Here Jingwu Z Zhang and colleagues find that in activated T cells, phosphorylation of FOXP3 promotes its tra...
Multimodal microtubule binding by the Ndc80 kinetochore complex
Microtubules bind to the kinetochore at the Ndc80 complex, and this interaction is regulated by phosphorylation events at the N-terminal tail of Ndc80, mediated by the Aurora B kinase. The distinct fu...
TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h
TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3hThe phytohormone Auxin activates the TOR pathway to dissociate inactive S6K1 from polysomes and to st...
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
Fox and colleagues report that VEGF-A stimulation of endothelial cells induces the phosphorylation of profilin by VEGFR2 and Src. This regulation promotes endothelial cell migration and angiogenesis i...
AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis
DNA damage activates the tumour suppressor p53, resulting in either cell-cycle arrest or apoptosis. One mechanism that selectively represses apoptosis-promoting genes involves phosphorylation of the t...
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Current understanding and importance of histone phosphorylation in regulating chromatin biology.
The core histones H2A, H2B, H3 and H4, undergo various post-translational modifications, such as acetylation, methylation and phosphorylation. Core histone phosphorylation has roles in several biologi...
Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated acutely by protein phosphorylation. No studies have systematically investigated the time course of TH ph...
Contraction Regulates Site-Specific Phosphorylation of TBC1D1 in Skeletal Muscle.
TBC1D1 is a Rab-GAP protein that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation and function. We studied TBC1D1 phosphorylation on three predicted AMPK phosphoryla...
Summary Background: Myosin IIA is an essential platelet contractile protein that is regulated by phosphorylation of its regulatory light chain (MLC) on residues (Thr)18 and (Ser)19 via the myosin ligh...
Inhibitory Phosphorylation of GSK-3 by CaMKII Couples Depolarization to Neuronal Survival.
Glycogen synthase kinase-3 (GSK-3) plays a critical role in neuronal apoptosis. The two mammalian isoforms of the kinase, GSK-3α and GSK-3β, are inhibited by phosphorylation at Ser-21 and Ser-9, res...
