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Sinovac provides update on EV71 vaccine Phase III trial on HFMD

Sinovac Biotech Ltd., a leading provider of biopharmaceutical products in China, today provided an update on its Phase III clinical trial progress and commercialization preparation for its proprietary...

[Comment] EV71 vaccine: protection from a previously neglected disease

The eagerly awaited results of a phase 3 trial of an inactivated enterovirus 71 (EV71) vaccine are reported by Feng-Cai Zhu and colleagues in The Lancet. EV71 is an important cause of hand, foot, and...

First-Ever Enterovirus 71 Vaccine Protects Young Children Against Common And Potentially Deadly Hand, Foot, And Mouth Disease

The first enterovirus 71 (EV71) vaccine candidate to reach phase 3 clinical testing provides young Chinese children with significant protection against disease caused by EV71, a growing public-health...

EV71 vaccine regulatory update

Vaccine protects kids against hand, foot and mouth disease

By Kate KellandReuters  Chinese scientists have developed the first vaccine to protect children against a virus called enterovirus 71, or EV71, that causes the common and sometimes deadly hand...

EV71: Vaccine Prevents Hand-Foot-Mouth, Associated Disease

The first vaccine against enterovirus 71 helps prevent hand, foot, and mouth disease, as well as EV71-associated disease, according to phase 3 trial results. Medscape Medical News

Sinovac files NDA for EV71 vaccine

Sinovac Biotech’s NDA for its proprietary EV71 vaccine has been accepted by the Beijing Drug Administration, which will conduct an on-site inspection of Sinovac's clinical trials and submit its  op...

Sinovac vaccine meets primary in Phase III trial

Sinovac Biotech Ltd. (NASDAQ:SVA) said its vaccine against human enterovirus 71 (EV71) met the primary endpoint of preventing hand, foot and mouth disease (HFMD) caused by EV71 vs. placebo in a Phase...

Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles.

Enterovirus type 71 (EV71) is a virulent form of enteroviruses causing hospitalizations for children less than three years of age. Currently there are no anti-viral therapies or vaccines available for...

The virology and developments toward control of human enterovirus 71.

Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, was first recognized as a dermotrophic virus that usually cause mild, self-limiting hand-foot-and-mouth disease (...

Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice.

Human PSGL-1 is a receptor for EV71 that facilitates EV71 entry and replication in mouse cells. We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line. Expr...

Enterovirus 71 Infection on Monocytes with Antibody-dependent Enhancement.

Enterovirus (EV) is a RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brainstem encephalitis (BE)...

Formaldehyde-inactivated human enterovirus 71 vaccine is compatible for co-immunization with a commercial pentavalent vaccine.

In this study we tested the effectiveness of a formaldehyde-inactivated EV71 vaccine and its compatibility for co-immunization with a pentavalent vaccine that contained inactivated poliovirus (PV) vac...